Schütte Olivia, Bachmann Larissa, Shivappa Nitin, Hebert James R, Felix Janine F, Röder Stefan, Sack Ulrich, Borte Michael, Kiess Wieland, Zenclussen Ana C, Stangl Gabriele I, Herberth Gunda, Junge Kristin M
Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, United States.
Front Nutr. 2022 Apr 8;9:868872. doi: 10.3389/fnut.2022.868872. eCollection 2022.
Lifestyle and environmental factors are known to contribute to allergic disease development, especially very early in life. However, the link between diet composition and allergic outcomes remains unclear.
In the present population-based cohort study we evaluated the dietary intake of 10-year-old children and analyses were performed with particular focus on atopic dermatitis or food allergy, allergic diseases known to be affected by dietary allergens. Dietary intake was assessed semi-quantitative food frequency questionnaires. Based on these data, individual nutrient intake as well as children's Dietary Inflammatory Index (C-DII™) scores were calculated. Information about atopic manifestations during the first 10 years of life and confounding factors were obtained from standardized questionnaires during pregnancy and annually thereafter.
Analyses from confounder-adjusted logistic regression models ( = 211) revealed that having atopic outcomes was associated with having a pro-inflammatory pattern at the age of 10 years: OR = 2.22 (95% CI: 1.14-4.31) for children with atopic dermatitis and OR = 3.82 (95% CI: 1.47-9.93) for children with food allergy in the first 10 years of life.
A pro-inflammatory dietary pattern might worsen the atopic outcome and reduce the buffering capacity of the individual against harmful environmental exposures or triggers. For pediatricians it is recommended to test for the individual tolerance of allergenic foods and to increase the nutrient density of tolerable food items to avoid undesirable effects of eating a pro-inflammatory diet.
已知生活方式和环境因素会导致过敏性疾病的发生，尤其是在生命早期。然而，饮食组成与过敏结局之间的联系仍不明确。
在本基于人群的队列研究中，我们评估了10岁儿童的饮食摄入量，并进行了分析，特别关注特应性皮炎或食物过敏，这两种过敏性疾病已知会受到饮食过敏原的影响。通过半定量食物频率问卷评估饮食摄入量。基于这些数据，计算个体营养素摄入量以及儿童饮食炎症指数（C-DII™）得分。关于生命最初10年的特应性表现和混杂因素的信息来自孕期及之后每年的标准化问卷。
对混杂因素调整后的逻辑回归模型（n = 211）分析显示，出现特应性结局与10岁时具有促炎模式相关：10岁前患有特应性皮炎的儿童，比值比（OR）= 2.22（95%置信区间：1.14 - 4.31）；患有食物过敏的儿童，OR = 3.82（95%置信区间：1.47 - 9.93）。
促炎饮食模式可能会使特应性结局恶化，并降低个体对有害环境暴露或触发因素的缓冲能力。建议儿科医生检测个体对致敏食物的耐受性，并提高可耐受食物的营养密度，以避免食用促炎饮食产生不良影响。
