Cummins R O, Eisenberg M S, Litwin P E, Graves J R, Hearne T R, Hallstrom A P
JAMA. 1987 Mar 27;257(12):1605-10.
In a randomized controlled clinical trial, the effectiveness of emergency medical technician (EMT) use of automatic external defibrillators (AEDs) was compared with EMT use of standard defibrillators for patients in cardiac arrest. A total of 321 cardiac arrest patients were treated during the study: 116 were treated by EMTs using the AED (AUTO group), 158 were treated by EMTs using the standard defibrillators (standard group), and 47 were treated by EMTs using the standard defibrillator when they were assigned to use the AED. There was no significant differences in hospital admission or discharge rates between the AUTO group (54% admitted, 28% discharged) and the standard group (52% admitted, 23% discharged) for patients in ventricular fibrillation (VF), for patients in non-VF rhythms, or for all patients combined. The only significant difference observed was in the time from power ON to first shock: 1.1 minutes average AUTO group and 2.0 minutes average standard group. The treatment groups did not differ significantly in sensitivity for VF (78% AED, 76% standard), specificity for non-VF rhythms (100% AED, 95% standard), or rates of defibrillation to a non-VF rhythm (62% AED, 57% standard). We conclude that in clinical outcomes and device performance, AEDs are comparable with standard defibrillators and should be considered an acceptable alternative. Automatic external defibrillators appear to have advantages over standard defibrillators in training, skill retention, and faster operation. Such devices can make early defibrillation available for a much larger portion of the population. They are a major innovation for the prehospital care of cardiac arrest patients.
在一项随机对照临床试验中,研究了急救医疗技术人员(EMT)使用自动体外除颤器(AED)与使用标准除颤器对心脏骤停患者进行治疗的效果。研究期间共治疗了321名心脏骤停患者:116名由使用AED的EMT进行治疗(AUTO组),158名由使用标准除颤器的EMT进行治疗(标准组),47名被分配使用AED的患者由使用标准除颤器的EMT进行治疗。对于室颤(VF)患者、非VF心律患者或所有合并患者,AUTO组(54%入院,28%出院)和标准组(52%入院,23%出院)在入院率或出院率方面无显著差异。观察到的唯一显著差异在于从开机到首次电击的时间:AUTO组平均为1.1分钟,标准组平均为2.0分钟。治疗组在VF敏感性(AED为78%,标准为76%)、非VF心律特异性(AED为100%,标准为95%)或转为非VF心律的除颤率(AED为62%,标准为57%)方面无显著差异。我们得出结论,在临床结果和设备性能方面,AED与标准除颤器相当,应被视为可接受的替代方案。自动体外除颤器在培训、技能保持和操作速度方面似乎优于标准除颤器。此类设备可为更多人群提供早期除颤。它们是心脏骤停患者院前护理的一项重大创新。