Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea.
Transfus Apher Sci. 2022 Oct;61(5):103450. doi: 10.1016/j.transci.2022.103450. Epub 2022 Apr 20.
ABO antibodies occur naturally and usually exist as alloantibodies. They are the most clinically significant in cases of transfusions. However, there are very few reports on auto-anti-A or B. A 58-year-old man visited our hospital for evaluation of an inguinal mass. Blood typing was performed, while preparing the patient for an excisional biopsy. Forward and reverse typing showed a typical AB and A pattern. Results of the direct antiglobulin and unexpected antibody screening tests were negative. The serum did not react with AB3 cells. The biopsy revealed a diffuse large B-cell lymphoma. After completing four cycles of R-CHOP chemotherapy, the patient achieved complete remission. There were no anti-B antibodies found on repeat ABO typing. This report shares our experience on unexpected anti-B antibody findings in a patient with an A1B blood type. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A1B blood type in Korea.
ABO 抗体是天然存在的，通常为同种抗体。在输血情况下，它们是最具临床意义的。然而，关于自身抗-A 或抗-B 的报道却很少。一位 58 岁男性因腹股沟肿块就诊于我院。在为患者行切除术活检前，进行了血型鉴定。正定型和反定型显示典型的 AB 和 A 型模式。直接抗球蛋白和意外抗体筛查试验结果均为阴性。血清与 AB3 细胞无反应。活检显示弥漫性大 B 细胞淋巴瘤。完成 4 个周期的 R-CHOP 化疗后，患者达到完全缓解。重复 ABO 定型时未发现抗-B 抗体。本报告分享了我们在 A1B 血型患者中发现意外抗-B 抗体的经验。据我们所知，这是韩国首例 A1B 血型患者出现抗-B 抗体的报告。
