Hou Jun, Jiang Changqing, Wen Xudong, Li Chengming, Xiong Shiqiang, Yue Tian, Long Pan, Shi Jianyou, Zhang Zhen
Department of Cardiology, Chengdu Third People's Hospital/Affiliated Hospital of Southwest Jiao Tong University, Chengdu, China.
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Front Pharmacol. 2022 Jul 13;13:949863. doi: 10.3389/fphar.2022.949863. eCollection 2022.
Cancer is a major public health problem around the world and the key leading cause of death in the world. It is well-known that glucolipid metabolism, immunoreaction, and growth/death pattern of cancer cells are markedly different from normal cells. Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and ferroptosis, which can be a promising potential target and biomarker for anticancer. Specifically, ACSL4 inhibits the progress of lung cancer, estrogen receptor (ER) positive breast cancer, cervical cancer and the up-regulation of ACSL4 can improve the sensitivity of cancer cells to ferroptosis by enhancing the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). However, it is undeniable that the high expression of ACSL4 in ER negative breast cancer, hepatocellular carcinoma, colorectal cancer, and prostate cancer can also be related with tumor cell proliferation, migration, and invasion. In the present review, we provide an update on understanding the controversial roles of ACSL4 in different cancer cells.
癌症是全球主要的公共卫生问题，也是全球主要的死亡原因。众所周知，癌细胞的糖脂代谢、免疫反应以及生长/死亡模式与正常细胞明显不同。最近发现，酰基辅酶A合成酶长链家族4（ACSL4）参与长链脂肪酸代谢的激活、免疫信号转导和铁死亡，这可能是一个有前景的潜在抗癌靶点和生物标志物。具体而言，ACSL4抑制肺癌、雌激素受体（ER）阳性乳腺癌、宫颈癌的进展，ACSL4的上调可通过增强脂质过氧化产物和致死性活性氧（ROS）的积累来提高癌细胞对铁死亡的敏感性。然而，不可否认的是，ACSL4在ER阴性乳腺癌、肝细胞癌、结直肠癌和前列腺癌中的高表达也可能与肿瘤细胞的增殖、迁移和侵袭有关。在本综述中，我们提供了关于理解ACSL4在不同癌细胞中争议性作用的最新情况。
