School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
FASEB J. 2022 May;36(5):e22311. doi: 10.1096/fj.202101900RR.
Dynein and kinesin are cytoskeletal motor proteins involved in transporting cellular cargos and viruses. Throughout viral infection, they actively participate in the virus life cycle in the cell during entry, genome replication, and departure. Through their retrograde and anterograde transport, dynein and kinesin assist in promoting viral infection as well as the cellular defense response. This review highlights the crucial roles kinesin and dynein play in facilitating viral proliferation and aims to exhibit these proteins as vital targets for drug discovery in exploring strategies for regulating their dual functions concerning involvements in various essential phases of viral infections and host cells' immune response.
动力蛋白和驱动蛋白是细胞骨架马达蛋白，参与运输细胞货物和病毒。在整个病毒感染过程中，它们在病毒进入、基因组复制和离开细胞的过程中积极参与病毒的生命周期。通过逆行和顺行运输，动力蛋白和驱动蛋白有助于促进病毒感染和细胞防御反应。本综述强调了驱动蛋白和动力蛋白在促进病毒增殖方面的关键作用，并旨在展示这些蛋白作为药物发现的重要靶点，以探索调节它们在病毒感染和宿主细胞免疫反应各个关键阶段的双重功能的策略。
