Medical Corps, Israel Defense Forces, Ramat-Gan, Israel.
Department of Military Medicine, Hebrew University, Jerusalem, Israel.
Spine (Phila Pa 1976). 2022 Jun 15;47(12):841-846. doi: 10.1097/BRS.0000000000004355. Epub 2022 Apr 21.
A cross-sectional study.
We designed this study to investigate the risk for spinal deformity among individuals whose parents had a spinal deformity.
Adolescent idiopathic scoliosis and Scheuermann kyphosis (SK) are common adolescent spinal deformities (ASD) with a significant impact on public health. Timely treatment with bracing is effective in halting or slowing the progression of these deformities. However, screening healthy adolescents for spinal deformities remains debatable. While the leading medical organizations endorse contradictory positions regarding the screening of the general population, there is a consensus that screening of targeted population should be considered. Due to their genetic predisposition, adolescents whose parents suffer from a spinal deformity may be candidates for targeted screening.
We conducted a nationwide, population-based study of 611,689 Israeli adolescents, aged 16 to 19 years old, who were screened for spinal deformities between the years 2000 and 2019. The data for this study were derived from a central database containing medical records of all adolescents who were examined preliminary to mandatory military service. In our study, ASD were strictly defined by plain x-ray.
Compared with adolescents of whose parents did not have a spinal deformity, the odds ratios (OR) for ASD among adolescents whose father, mother, or both parents had spinal deformity were 1.46, 1.74, and 2.58, respectively. These ratios were consistent in multivariate models.
We have found a considerable increased risk for adolescent spinal deformities among adolescents whose parents suffered from spinal deformities. We believe that our findings should serve the leading medical organizations when considering the screening of targeted populations.
一项横断面研究。
我们设计本研究旨在调查父母患有脊柱畸形的个体发生脊柱畸形的风险。
青少年特发性脊柱侧凸和Scheuermann 后凸（SK）是常见的青少年脊柱畸形（ASD），对公共健康有重大影响。使用支具进行及时治疗可有效阻止或减缓这些畸形的进展。然而，对健康青少年进行脊柱畸形筛查仍存在争议。尽管主要医疗组织对普通人群的筛查持相反立场，但一致认为应考虑对特定人群进行筛查。由于遗传易感性，父母患有脊柱畸形的青少年可能是有针对性筛查的候选者。
我们对 611,689 名 16 至 19 岁的以色列青少年进行了一项全国性、基于人群的研究，这些青少年在 2000 年至 2019 年期间接受了脊柱畸形筛查。本研究的数据来自一个中央数据库，其中包含所有接受强制性兵役前体检的青少年的医疗记录。在我们的研究中，ASD 严格通过 X 光片定义。
与父母没有脊柱畸形的青少年相比，父亲、母亲或父母双方有脊柱畸形的青少年发生 ASD 的比值比（OR）分别为 1.46、1.74 和 2.58。这些比值在多变量模型中是一致的。
我们发现父母患有脊柱畸形的青少年发生青少年脊柱畸形的风险显著增加。我们认为，我们的发现应在考虑对特定人群进行筛查时为主要医疗组织提供参考。
4 级。
