Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Department of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Sci Total Environ. 2022 Aug 15;834:155514. doi: 10.1016/j.scitotenv.2022.155514. Epub 2022 Apr 25.
Growing evidence suggests that cold exposure is to some extent a potential risk factor for ischemic stroke. At present, although the mechanism by which cold exposure induces ischemic stroke is not fully understood, some potential mechanisms have been mentioned. First, the seasonal and temperature variability of cerebrovascular risk factors (hypertension, hyperglycemia, hyperlipidemia, atrial fibrillation) may be involved. Moreover, the activation of sympathetic nervous system and renin-angiotensin system and their downstream signaling pathways (pro-inflammatory AngII, activated platelets, and dysfunctional immune cells) are also major contributors. Finally, the influenza epidemics induced by cold weather are also influencing factors that cannot be ignored. This article is the first to systematically and comprehensively describe the underlying mechanism of cold-induced ischemic stroke, aiming to provide more preventive measures and medication guidance for stroke-susceptible individuals in cold season, and also provide support for the formulation of public health policies.
越来越多的证据表明，寒冷暴露在某种程度上是缺血性中风的一个潜在危险因素。目前，尽管寒冷暴露导致缺血性中风的机制尚未完全阐明，但已经提到了一些潜在的机制。首先，可能涉及脑血管危险因素（高血压、高血糖、高血脂、心房颤动）的季节性和温度变异性。此外，交感神经系统和肾素-血管紧张素系统及其下游信号通路（促炎 AngII、激活的血小板和功能失调的免疫细胞）的激活也是主要贡献者。最后，寒冷天气引起的流感疫情也是不可忽视的影响因素。本文首次系统全面地描述了寒冷诱导缺血性中风的潜在机制，旨在为寒冷季节易患中风的个体提供更多的预防措施和药物指导，并为公共卫生政策的制定提供支持。
