Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, 3584 CM Utrecht, The Netherlands.
Vet J. 2022 May-Jun;283-284:105830. doi: 10.1016/j.tvjl.2022.105830. Epub 2022 Apr 25.
Many domesticated horses have gastric ulcers which can be diagnosed and graded during gastroscopy. A distinction should be made between equine squamous gastric disease (ESGD), which is caused by exposure of the mucosa to acid, and equine glandular gastric disease (EGGD), thought to occur when mucosal defence mechanisms are compromised. Horses with gastric ulcers may, but do not always, show clinical signs such as poor appetite, mild colic, discomfort during girthing, behavioural changes and reduced performance. The mainstay of treatment is blocking acid production using the proton pump inhibitor omeprazole. Treatment is usually successful in cases of ESGD, but less so for EGGD, where treatment duration is longer and for which sucralfate may be added or alternatives necessary, such as misoprostol, a prostaglandin analogue. To prevent recurrence of ulcers known risk factors, such as high concentrate diets, intense exercise and stress should be avoided or minimized.
许多驯养马患有胃溃疡，可以通过胃镜检查进行诊断和分级。应区分马的鳞状胃疾病（ESGD）和马的腺胃疾病（EGGD），前者是由胃黏膜暴露于酸引起的，后者被认为是在黏膜防御机制受损时发生的。患有胃溃疡的马可能会出现，但并非总是出现食欲不振、轻度绞痛、系扣时不适、行为改变和运动表现下降等临床症状。治疗的主要方法是使用质子泵抑制剂奥美拉唑抑制胃酸生成。ESGD 的治疗通常是成功的，但 EGGD 则不然，其治疗时间更长，可能需要添加硫糖铝或其他替代药物，如前列腺素类似物米索前列醇。为了防止溃疡复发，应避免或尽量减少已知的危险因素，如高浓缩饲料、剧烈运动和应激。
