Pediatric Infectious Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Tel-Hashomer, Israel.
Int J Infect Dis. 2022 Jul;120:205-209. doi: 10.1016/j.ijid.2022.04.037. Epub 2022 Apr 25.
To compare infection rates and circulating subtypes of human metapneumovirus (hMPV) before (2019-2020) and after the emergence of coronavirus disease 2019 (COVID-19) (2021) in Israel.
In total, 12,718 respiratory samples were collected from hospitalized patients of all ages during the years 2019 to 2021 at the Sheba Medical Center in Israel and subjected to reverse transcription-polymerase chain reaction analysis. In addition, whole-genome sequencing was performed to characterize the subtypes of hMPV circulating in Israel between 2019 and 2021.
A total of 481 samples were found positive for hMPV. Before the emergence of COVID-19, hMPV peaked in winter months and declined thereafter. In sharp contrast, during the COVID-19 pandemic, we observed a delayed peak in hMPV infection cases and higher infection of young children. Viral sequencing showed a shift in the most prevalent circulating hMPV strain from A2b to B1 during the years 2019, 2020, and 2021.
Compared with the years before the COVID-19 pandemic, in 2021, hMPV mostly affected young children, and the most prevalent circulating subtype shifted from A2b in 2019 to B1.
比较 2019-2020 年（新冠疫情前）和 2021 年（新冠疫情后）以色列人类偏肺病毒（hMPV）感染率和循环亚型。
2019 年至 2021 年期间，在以色列的谢巴医疗中心，共收集了来自各年龄段住院患者的 12718 份呼吸道样本，并进行逆转录-聚合酶链反应分析。此外，还进行了全基因组测序，以分析 2019 年至 2021 年期间在以色列流行的 hMPV 亚型。
共发现 481 份 hMPV 阳性样本。在新冠疫情出现之前，hMPV 在冬季达到高峰，之后呈下降趋势。相比之下，在新冠疫情期间，我们观察到 hMPV 感染病例的高峰期延迟，且年幼儿童的感染率更高。病毒测序显示，在 2019 年、2020 年和 2021 年，最流行的循环 hMPV 株从 A2b 转变为 B1。
与新冠疫情前的年份相比，2021 年 hMPV 主要影响年幼儿童，且最流行的循环亚型从 2019 年的 A2b 转变为 B1。
