Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Sep;14(5):e1805. doi: 10.1002/wnan.1805. Epub 2022 Apr 27.
Polydopamine (PDA) is an artificial melanin polymer that has been spotlighted due to its extraordinary optoelectronic characteristics and advance theranosctic applications in biomaterial fields. Moreover, interactions on the nano-bio interface interplay whereby substances exchange in response to endogenous or exogenous stimuli, and electron transfer driven by light, energy-level transitions, or electric field greatly affect the functional performance of PDA-modified nanoparticles. The full utilization of potential in PDA's interfacial activities, optoelectrical properties and related responsiveness is therefore an attractive means to construct advanced nanostructures for regulating biological processes and metabolic pathways. Herein, we strive to summarize recent advances in the construction of functional PDA-based nanomaterials with state-of-the-art architectures prepared for modulation of photoelectric sensing and redox reversibility, as well as manipulation of photo-activated therapeutics. Meanwhile, contributions of interfacial electron transfer and matter conversion are highlighted by discussing the structure-property-function relationships and the biological effects in their featured applications including disease theranostics, antibacterial activities, tissue repair, and combined therapy. Finally, the current challenges and future perspectives in this emerging research field will also be outlined. Recent advances on polydopamine-based nanotherapeutics with an emphasis on their interfacial activities, optoelectrical properties and related responsiveness are reviewed for providing insightful guidance to the rational design of integrated theranostic nanoplatforms with high performance in the biomedical fields. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
聚多巴胺（PDA）是一种人工黑色素聚合物，由于其非凡的光电特性和在生物材料领域的先进治疗应用而受到关注。此外，纳米-生物界面上的相互作用，物质在内外源刺激下交换，以及光、能量水平跃迁或电场驱动的电子转移，极大地影响了 PDA 修饰纳米粒子的功能性能。因此，充分利用 PDA 界面活性、光电特性和相关响应性的潜力，是构建用于调节生物过程和代谢途径的先进纳米结构的一种有吸引力的方法。在此，我们努力总结了近年来构建具有先进结构的功能性 PDA 基纳米材料的最新进展，这些纳米材料用于调制光电传感和氧化还原可逆性，以及操纵光激活治疗。同时，通过讨论结构-性质-功能关系及其在包括疾病治疗、抗菌活性、组织修复和联合治疗在内的特色应用中的生物学效应，突出了界面电子转移和物质转化的贡献。最后，还概述了该新兴研究领域当前的挑战和未来展望。本文重点介绍了基于 PDA 的纳米治疗剂的最新进展，强调了其界面活性、光电特性和相关响应性，为合理设计具有高性能的集成治疗诊断纳米平台提供了有见地的指导，该平台在生物医学领域具有广泛的应用。本文属于以下分类：诊断工具 > 诊断纳米器件治疗方法和药物发现 > 肿瘤治疗的纳米医学 纳米技术生物学应用 > 生物学中的纳米级系统。
