Kedzierska Katherine, Thomas Paul G
Department of Microbiology and Immunology at Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cell Rep Med. 2022 Feb 25;3(3):100562. doi: 10.1016/j.xcrm.2022.100562. eCollection 2022 Mar 15.
Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope-specific CD8 and CD4 T cell responses toward SARS-CoV-2 infection and vaccination, their subsequent persistence into long-term memory, and ongoing work to determine their role in limiting disease severity.
在许多感染中，强大的T细胞反应与较轻的疾病结局相关。T细胞还会建立长期记忆库，并且由于它们主要针对包含保守肽段的表位，所以能够对包括奥密克戎在内的新冠病毒变体产生反应。在此，我们讨论针对新冠病毒感染和疫苗接种的表位特异性CD8和CD4 T细胞反应、它们随后持续形成长期记忆的情况，以及为确定它们在限制疾病严重程度方面的作用而正在进行的研究工作。
