Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Vet Med Sci. 2022 Jul;8(4):1434-1442. doi: 10.1002/vms3.821. Epub 2022 Apr 27.
Evidence-based guidelines for determining dietary management in dogs with megaoesophagus are lacking.
This study looked to compare oesophageal clearance times (ECT) of liquid and two food consistencies using a contrast videofluoroscopy feeding evaluation, and to assess if recommendations made based on findings could improve regurgitation and quality of life in dogs with congenital megaoesophagus.
Twenty-one dogs with congenital megaoesophagus and nine healthy dogs received liquid, slurry, and meatball diets containing barium while in an upright position. Follow-up was performed to determine response to recommendations.
Healthy dogs had significantly shorter median ECT for all consistencies (p < 0.001). In the megaoesophagus group, ECT varied by consistency and individual. The number of dogs in the megaoesophagus group with complete clearance was four (median ECT 10 min) for liquid, five (median ECT 5 min) for slurry, and two (median ECT 5 and 30 min, respectively) for meatballs. Partial clearance was seen in 11 dogs (median clearance 25%) with liquid, seven with slurry (median clearance 50%), and five with meatballs (median clearance 60%). Recommendations included altering current medications (13/21 dogs), diet consistency (6/21), time upright (12/21), water delivery (21/21), and adding activity (7/21). Regurgitation episodes/week decreased significantly from 5.5 to 2.5 (p < 0.001) at follow-up 3-5 weeks post-evaluation, with 95% of owners reporting improvement in quality of life. Seventy percent were alive 46-777 days after last recheck. Three dogs died from megaoesophagus associated complications (median survival 461 days after diagnosis).
The findings of this study suggest that a videofluoroscopic feeding evaluation may help guide management of dogs with congenital megaoesophagus.
目前缺乏针对巨食道犬饮食管理的循证指南。
本研究旨在通过对比透视荧光检查评估食管清除时间（ECT），比较液体和两种食物稠度的 ECT，并评估基于检查结果提出的建议是否能改善先天性巨食道犬的反流和生活质量。
21 只先天性巨食道犬和 9 只健康犬在直立位时接受含钡的液体、糊状和肉丸饮食。进行随访以确定对建议的反应。
健康犬所有稠度的 ECT 中位数均显著较短（p < 0.001）。在巨食道犬组中，ECT 因稠度和个体而异。在液体中，4 只犬（ECT 中位数 10 分钟）完全清除，5 只犬（ECT 中位数 5 分钟）在糊状中，2 只犬（ECT 中位数分别为 5 分钟和 30 分钟）在肉丸中完全清除。11 只犬（液体中位清除率 25%）、7 只犬（糊状中位清除率 50%）和 5 只犬（肉丸中位清除率 60%）部分清除。建议包括改变现有药物（21 只犬中的 13 只）、饮食稠度（21 只犬中的 6 只）、直立时间（21 只犬中的 12 只）、水输送（21 只犬）和增加活动（21 只犬中的 7 只）。在评估后 3-5 周的随访中，反流发作/周显著从 5.5 次减少到 2.5 次（p < 0.001），95%的主人报告生活质量改善。70%的犬在最后一次复查后 46-777 天仍存活。3 只犬死于巨食道相关并发症（中位生存期为诊断后 461 天）。
本研究结果表明，透视荧光检查评估可能有助于指导先天性巨食道犬的管理。
