The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Cell Biol Int. 2022 Jul;46(7):997-1008. doi: 10.1002/cbin.11804. Epub 2022 Apr 27.
Ferroptosis is an iron-dependent nonapoptotic regulated cell death, which is mainly caused by an abnormal increase in lipid oxygen free radicals and an imbalance in redox homeostasis. Recently, ferroptosis has been shown to have implications in various gastrointestinal cancers, such as gastric carcinoma, hepatocellular carcinoma, and pancreatic cancer. This review summarises the latest research on ferroptosis, its mechanism of action, and its role in the progression of different gastrointestinal tumors to provide more information regarding the prevention and treatment of these tumors.
铁死亡是一种铁依赖性的非凋亡性细胞死亡，主要由脂质氧自由基异常增加和氧化还原平衡失调引起。最近，铁死亡被证明与多种胃肠道癌有关，如胃癌、肝癌和胰腺癌。本综述总结了铁死亡及其作用机制的最新研究进展，以及其在不同胃肠道肿瘤进展中的作用，为这些肿瘤的预防和治疗提供了更多信息。
