Yang Lei, Guan Yu, Liu Zhanbing
Department of General Surgery, Peking University First Hospital, Beijing, China.
Front Pharmacol. 2023 Apr 13;14:1177405. doi: 10.3389/fphar.2023.1177405. eCollection 2023.
Ferroptosis is a newly discovered form of programmed cell death that involves the accumulation of iron-dependent lipid peroxides and plays a vital role in the tumorigenesis, development, and drug resistance of various tumors such as hepatocellular carcinoma (HCC). As a hotspot in molecular biology, non-coding RNAs (ncRNAs) participate in the initiation and progression of HCC, either act as oncogenes or tumor suppressors. Recent studies have shown that ncRNAs can regulate ferroptosis in HCC cells, which would affect the tumor progression and drug resistance. Therefore, clarifying the underlying role of ferroptosis and the regulatory role of ncRNA on ferroptosis in HCC could develop new treatment interventions for this disease. This review briefly summarizes the role of ferroptosis and ferroptosis-related ncRNAs in HCC tumorigenesis, progression, treatment, drug resistance and prognosis, for the development of potential therapeutic strategies and prognostic markers in HCC patients.
铁死亡是一种新发现的程序性细胞死亡形式，涉及铁依赖性脂质过氧化物的积累，在肝细胞癌（HCC）等各种肿瘤的发生、发展和耐药性中起着至关重要的作用。作为分子生物学的一个热点，非编码RNA（ncRNAs）参与HCC的起始和进展，既可以作为癌基因，也可以作为肿瘤抑制因子。最近的研究表明，ncRNAs可以调节HCC细胞中的铁死亡，这将影响肿瘤进展和耐药性。因此，阐明铁死亡的潜在作用以及ncRNA对HCC中铁死亡的调节作用，可能为这种疾病开发新的治疗干预措施。本综述简要总结了铁死亡和铁死亡相关ncRNAs在HCC肿瘤发生、进展、治疗、耐药性和预后中的作用，以期为HCC患者开发潜在的治疗策略和预后标志物。
