Department of Food and Nutrition, College of BioNano Technology, Gachon University, Gyeonggi-do 13120, Korea.
Department of Chemistry, Indian Institute of Petroleum and Energy, Visakhapatnam 530003, Andhra Pradesh, India.
ACS Biomater Sci Eng. 2022 May 9;8(5):2131-2141. doi: 10.1021/acsbiomaterials.1c01598. Epub 2022 Apr 27.
Insufficient glucose control remains a critical challenge for type 2 diabetes mellitus (T2DM) patients with currently used therapeutic drugs, which can also have detrimental side effects. The facile synthesis of nitrogen-doped carbon nanorods (N-CNRs) as therapeutic agents in a T2DM transgenic db/db mouse model is reported herein. N-CNRs are synthesized from silkworm powder without the assistance of any template and possess a hollow graphitic nature, rough surface, and good aqueous solubility, which make them ideal candidates for fabricating nanomedicines. N-CNRs are employed to reduce fasting blood glucose and ameliorate serum biomarker levels linked to oxidative stress and inflammation. Interestingly, through the downregulation of enhanced expression of glutathione peroxidase, superoxide dismutase, and catalase as well as inflammatory responses, N-CNRs reverse pancreatic dysfunction and normalize the secretory functions of pancreatic cells. Moreover, hepatic steatosis is attenuated by downregulating lipogenesis and increasing fatty acid oxidation. This finding may help in designing novel therapeutics for T2DM treatment.
目前使用的治疗药物，对于 2 型糖尿病（T2DM）患者来说，血糖控制仍然不足，这也可能会产生有害的副作用。本文报道了一种简便的方法，可将氮掺杂碳纳米棒（N-CNRs）作为治疗剂，应用于 T2DM 转基因 db/db 小鼠模型中。N-CNRs 是由蚕蛹粉合成的，无需任何模板辅助，具有中空石墨特性、粗糙表面和良好的水溶性，使其成为制造纳米药物的理想候选材料。N-CNRs 可用于降低空腹血糖，并改善与氧化应激和炎症相关的血清生物标志物水平。有趣的是，通过下调谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶以及炎症反应的增强表达，N-CNRs 逆转了胰腺功能障碍，并使胰腺细胞的分泌功能正常化。此外，通过下调脂肪生成和增加脂肪酸氧化，肝脂肪变性得到了缓解。这一发现可能有助于设计用于治疗 T2DM 的新型疗法。
