Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Mol Cell. 2022 May 5;82(9):1616-1630. doi: 10.1016/j.molcel.2022.04.006. Epub 2022 Apr 26.
SMC protein complexes are molecular machines that provide structure to chromosomes. These complexes bridge DNA elements and by doing so build DNA loops in cis and hold together the sister chromatids in trans. We discuss how drastic conformational changes allow SMC complexes to build such intricate DNA structures. The tight regulation of these complexes controls fundamental chromosomal processes such as transcription, recombination, repair, and mitosis.
SMC 蛋白复合物是为染色体提供结构的分子机器。这些复合物连接 DNA 元件，从而在顺式构建 DNA 环，并在反式将姐妹染色单体保持在一起。我们讨论了剧烈的构象变化如何使 SMC 复合物能够构建如此复杂的 DNA 结构。这些复合物的严格调控控制着转录、重组、修复和有丝分裂等基本染色体过程。
