猪部分肝切除肝脏的原位移植

Orthotopic transplantation of partially hepatectomized liver in the pig.

作者信息

Rossi G, de Carlis L, Doglia M, Fassati L R, Tarenzi L, Galmarini D

出版信息

Transplantation. 1987 Mar;43(3):362-5. doi: 10.1097/00007890-198703000-00009.

DOI:10.1097/00007890-198703000-00009

Abstract

One of the major technical obstacles to liver transplantation in children is to find a liver of appropriate size because of the rarity of child donors. To overcome this difficulty an experimental study was carried out using only a portion of the donor liver (right liver) transplanted orthotopically in pigs. A group of 15 allotransplants were performed. A left hepatectomy of the liver graft was performed ex situ and the right liver amounted to 55% of the whole liver. A total of 13 animals survived for more than 5 days (5 to 30 days, with an average of 16). Upon killing, the liver weight was considerably more than that of the part transplanted. The absence of technical complications suggests that this procedure is safe and feasible.

摘要

儿童肝移植的主要技术障碍之一是由于儿童供体稀缺而难以找到大小合适的肝脏。为克服这一困难，开展了一项实验研究，仅将供体肝脏的一部分（右肝）原位移植到猪体内。共进行了15例同种异体移植。在体外对移植肝脏进行左肝切除，右肝占全肝的55%。共有13只动物存活超过5天（5至30天，平均16天）。处死时，肝脏重量明显大于移植部分的重量。未出现技术并发症表明该手术安全可行。