使用MnO将醇选择性氧化为醛。

Okamura Hironori, Yasuno Yoko, Nakayama Atsushi, Kumadaki Katsushi, Kitsuwa Kohei, Ozawa Keita, Tamura Yusaku, Yamamoto Yuki, Shinada Tetsuro

Graduate School of Science, Osaka City University Sugimoto, Sumiyoshi Osaka 558-8585 Japan

RSC Adv. 2021 Aug 24;11(46):28530-28534. doi: 10.1039/d1ra05405h. eCollection 2021 Aug 23.

The selective oxidation of alcohol- to prepare aldehyde- was newly developed by means of NaBD reduction/activated MnO oxidation. Various aldehyde- derivatives including aromatic and unsaturated aldehyde- can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.

通过NaBD还原/活化MnO氧化法新开发了一种将醇选择性氧化制备醛的方法。可以制备各种醛衍生物，包括芳香醛和不饱和醛，氘掺入率高（高达98%D）。在温和条件下，底物中的卤素（氯、溴和碘）、烯烃、炔烃、酯、硝基和氰基均可耐受。