Gurawa Aakanksha, Kumar Manoj, Kashyap Sudhir
Carbohydrate Chemistry Research Laboratory (CCRL), Department of Chemistry, Malaviya National Institute of Technology Jaipur, (MNIT) Jaipur-302017 India
RSC Adv. 2021 May 27;11(31):19310-19315. doi: 10.1039/d1ra03209g. eCollection 2021 May 24.
A MeSI-mediated simple and efficient protocol for the chemoselective deprotection of acetyl groups has been developed employing KMnO as an additive. This chemoselective deacetylation is amenable to a wide range of substrates, tolerating diverse and sensitive functional groups in carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The protocol is attractive because it uses an environmentally benign reagent system to perform quantitative and clean transformations under ambient conditions.
已经开发出一种由甲磺酰亚胺（MeSI）介导的、使用高锰酸钾（KMnO）作为添加剂的用于乙酰基化学选择性脱保护的简单高效方法。这种化学选择性脱乙酰化适用于多种底物，能耐受碳水化合物、氨基酸、天然产物、杂环化合物和一般支架结构中各种不同且敏感的官能团。该方法具有吸引力，因为它使用了对环境友好的试剂体系，在环境条件下进行定量且清洁的转化。
