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无线磁共振动力可逆定向锁定胶囊机器人。

Wireless MRI-Powered Reversible Orientation-Locking Capsule Robot.

机构信息

Department of Physical Intelligence Max Planck Institute for Intelligent Systems Stuttgart 70569, Germany.

出版信息

Adv Sci (Weinh). 2021 Jul;8(13):2100463. doi: 10.1002/advs.202100463. Epub 2021 May 3.

Abstract

Magnetic resonance imaging (MRI) scanners do not provide only high-resolution medical imaging but also magnetic robot actuation and tracking. However, the rotational motion capabilities of MRI-powered wireless magnetic capsule-type robots have been limited due to the very high axial magnetic field inside the MRI scanner. Medical functionalities of such robots also remain a challenge due to the miniature robot designs. Therefore, a wireless capsule-type reversible orientation-locking robot (REVOLBOT) is proposed that has decoupled translational motion and planar orientation change capability by locking and unlocking the rotation of a spherical ferrous bead inside the robot on demand. Such an on-demand locking/unlocking mechanism is achieved by a phase-changing wax material in which the ferrous bead is embedded inside. Controlled and on-demand hyperthermia and drug delivery using wireless power transfer-based Joule heating induced by external alternating magnetic fields are the additional features of this robot. The experimental feasibility of the REVOLBOT prototype with steerable navigation, medical function, and MRI tracking capabilities with an 1.33 Hz scan rate is demonstrated inside a preclinical 7T small-animal MRI scanner. The proposed robot has the potential for future clinical use in teleoperated minimally invasive treatment procedures with hyperthermia and drug delivery capabilities while being wirelessly powered and monitored inside MRI scanners.

摘要

磁共振成像(MRI)扫描仪不仅提供高分辨率的医学成像,还能实现磁机器人的驱动和跟踪。然而,由于 MRI 扫描仪内部的轴向磁场非常高,因此由 MRI 驱动的无线磁胶囊式机器人的旋转运动能力受到限制。由于机器人的微型设计,此类机器人的医疗功能仍然是一个挑战。因此,提出了一种无线胶囊式可反转定位锁定机器人(REVOLBOT),它通过按需锁定和解锁机器人内部球形铁珠的旋转,实现了平移运动和解耦的平面定向变化能力。这种按需锁定/解锁机构是通过嵌入铁珠的相变蜡材料实现的。使用外部交变磁场感应的无线功率传输基于焦耳加热的受控和按需热疗和药物输送是该机器人的附加功能。在临床前 7T 小动物 MRI 扫描仪内,演示了具有可导航、医疗功能和 MRI 跟踪能力的 REVOLBOT 原型的实验可行性,其扫描速率为 1.33Hz。该机器人有望在具有热疗和药物输送能力的远程微创治疗程序中得到未来的临床应用,同时在 MRI 扫描仪内进行无线供电和监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2193/9158077/7666fead9303/ADVS-8-2100463-g002.jpg

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