• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

饮食诱导的肥胖通过 CX3CL1/CX3CR1 轴促进胰腺导管腺癌的肝转移。

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis.

机构信息

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200240, China.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, China.

出版信息

J Immunol Res. 2022 Apr 18;2022:5665964. doi: 10.1155/2022/5665964. eCollection 2022.

DOI:10.1155/2022/5665964
PMID:35478937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9038430/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of death in PDAC. Diet-induced obesity (DIO) is a risk factor for PDAC, and it remains unclear whether and how DIO contributes to liver metastasis of PDAC. In our study, we found that DIO significantly promoted PDAC liver metastasis compared with normal diet (ND) in intrasplenic injection mouse model. RNA-seq analysis for liver metastasis nodules showed that the various chemokines and several chemokine receptors were altered between ND and DIO samples. The expression levels of CX3CL1 and CX3CR1 were significantly upregulated in DIO-induced liver metastasis of PDAC compared to ND. Increased CX3CL1 promoted the recruitment of CX3CR1-expressing pancreatic tumor cells. Taken together, our data demonstrated that DIO promoted PDAC liver metastasis via CX3CL1/CX3CR1 axis.

摘要

胰腺导管腺癌 (PDAC) 是最具侵袭性的癌症之一，患者通常被诊断为远处转移。肝脏是远处转移的首选器官之一，肝转移是 PDAC 患者死亡的主要原因。饮食诱导的肥胖 (DIO) 是 PDAC 的一个危险因素，但尚不清楚 DIO 是否以及如何促进 PDAC 的肝转移。在我们的研究中，我们发现与正常饮食 (ND) 相比，DIO 在脾内注射小鼠模型中显著促进了 PDAC 的肝转移。对肝转移结节的 RNA-seq 分析表明，ND 和 DIO 样本之间存在多种趋化因子和几种趋化因子受体的改变。与 ND 相比，DIO 诱导的 PDAC 肝转移中 CX3CL1 和 CX3CR1 的表达水平显著上调。CX3CL1 的增加促进了表达 CX3CR1 的胰腺肿瘤细胞的募集。总之，我们的数据表明，DIO 通过 CX3CL1/CX3CR1 轴促进了 PDAC 的肝转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/f10c2b4c715f/JIR2022-5665964.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/35dc60895c9f/JIR2022-5665964.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/f3aa960aceb6/JIR2022-5665964.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/80b0d342fa85/JIR2022-5665964.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/8ae5acb10af3/JIR2022-5665964.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/f10c2b4c715f/JIR2022-5665964.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/35dc60895c9f/JIR2022-5665964.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/f3aa960aceb6/JIR2022-5665964.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/80b0d342fa85/JIR2022-5665964.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/8ae5acb10af3/JIR2022-5665964.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cfc/9038430/f10c2b4c715f/JIR2022-5665964.005.jpg

相似文献

1
Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis.饮食诱导的肥胖通过 CX3CL1/CX3CR1 轴促进胰腺导管腺癌的肝转移。
J Immunol Res. 2022 Apr 18;2022:5665964. doi: 10.1155/2022/5665964. eCollection 2022.
2
Fractalkine/CX3CR1 axis modulated the development of pancreatic ductal adenocarcinoma via JAK/STAT signaling pathway.趋化因子/ CX3CR1轴通过JAK/STAT信号通路调节胰腺导管腺癌的发展。
Biochem Biophys Res Commun. 2017 Dec 2;493(4):1510-1517. doi: 10.1016/j.bbrc.2017.10.006. Epub 2017 Oct 3.
3
Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis.CX3CR1 在胰腺癌发生过程中的早期表达。
Br J Cancer. 2013 Oct 29;109(9):2424-33. doi: 10.1038/bjc.2013.565. Epub 2013 Oct 1.
4
High expression of CX3CL1/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma.CX3CL1/CX3CR1 轴的高表达预示着胰腺导管腺癌预后不良。
J Gastrointest Surg. 2012 Aug;16(8):1493-8. doi: 10.1007/s11605-012-1921-7. Epub 2012 May 26.
5
Inhibition of CXCR1 reduces cell motility and viability in pancreatic adenocarcinoma epithelial cells.抑制CXCR1可降低胰腺腺癌上皮细胞的细胞运动性和活力。
Biochem Biophys Res Commun. 2018 Jan 15;495(3):2264-2269. doi: 10.1016/j.bbrc.2017.12.116. Epub 2017 Dec 21.
6
The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma.趋化因子受体CX3CR1参与胰腺导管腺癌的神经嗜性和恶性行为。
Cancer Res. 2008 Nov 1;68(21):9060-9. doi: 10.1158/0008-5472.CAN-08-1810.
7
The miR-561-5p/CXCL1 Signaling Axis Regulates Pulmonary Metastasis in Hepatocellular Carcinoma Involving CXCR1 Natural Killer Cells Infiltration.miR-561-5p/CXCL1 信号轴调控涉及 CXCR1 自然杀伤细胞浸润的肝细胞癌肺转移
Theranostics. 2019 Jul 9;9(16):4779-4794. doi: 10.7150/thno.32543. eCollection 2019.
8
CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice.CX3CL1-CX3CR1信号缺陷加剧雄性小鼠肥胖诱导的炎症和胰岛素抵抗。
Endocrinology. 2021 Jun 1;162(6). doi: 10.1210/endocr/bqab064.
9
MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion.MUC16 通过上调 NRP2 相关细胞黏附促进胰腺导管腺癌肝转移。
Mol Cancer Res. 2022 Aug 5;20(8):1208-1221. doi: 10.1158/1541-7786.MCR-21-0888.
10
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.缺氧诱导因子-1α 通过直接转录激活 CX3CR1 基因调节胰腺导管腺癌细胞的趋化迁移。
PLoS One. 2012;7(8):e43399. doi: 10.1371/journal.pone.0043399. Epub 2012 Aug 27.

引用本文的文献

1
Decoding the obesity-cancer connection: lessons from preclinical models of pancreatic adenocarcinoma.解析肥胖与癌症的关联：胰腺腺癌细胞模型的启示。
Life Sci Alliance. 2023 Aug 30;6(11). doi: 10.26508/lsa.202302228. Print 2023 Nov.
2
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma.转移性胰腺导管腺癌中免疫抑制的分子和代谢调控。
Mol Cancer. 2023 Jul 24;22(1):118. doi: 10.1186/s12943-023-01813-y.

本文引用的文献

1
Liver metastases.肝转移。
Nat Rev Dis Primers. 2021 Apr 15;7(1):27. doi: 10.1038/s41572-021-00261-6.
2
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
3
High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network.高脂肪饮食在胰岛素抵抗的小鼠模型中诱导广泛的磷酸酪氨酸信号网络重排。
Mol Syst Biol. 2019 Aug;15(8):e8849. doi: 10.15252/msb.20198849.
4
Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.致癌性 KRAS 降低高脂肪饮食小鼠胰岛细胞中 FGF21 的表达，从而促进胰腺肿瘤发生。
Gastroenterology. 2019 Nov;157(5):1413-1428.e11. doi: 10.1053/j.gastro.2019.07.030. Epub 2019 Jul 25.
5
PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.过氧化物酶体增殖物激活受体 δ 介导膳食脂肪促进结直肠癌转移的作用。
Cancer Res. 2019 Sep 1;79(17):4480-4490. doi: 10.1158/0008-5472.CAN-19-0384. Epub 2019 Jun 25.
6
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors.胰腺癌的流行病学：全球趋势、病因及风险因素
World J Oncol. 2019 Feb;10(1):10-27. doi: 10.14740/wjon1166. Epub 2019 Feb 26.
7
Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC).胰腺导管腺癌 (PDAC) 的治疗趋势。
Expert Opin Investig Drugs. 2019 Feb;28(2):161-177. doi: 10.1080/13543784.2019.1557145. Epub 2018 Dec 16.
8
CX3CL1 involves in breast cancer metastasizing to the spine via the Src/FAK signaling pathway.CX3CL1通过Src/FAK信号通路参与乳腺癌向脊柱转移。
J Cancer. 2018 Sep 8;9(19):3603-3612. doi: 10.7150/jca.26497. eCollection 2018.
9
Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8 T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients.鉴定趋化因子（CX3CL1）在肥胖相关癌症患者大网膜中记忆性 CD8 T 细胞积聚中的新作用。
Front Immunol. 2018 Aug 13;9:1867. doi: 10.3389/fimmu.2018.01867. eCollection 2018.
10
CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway.CX3CL1/fractalkine 通过激活Src/FAK 通路增强前列腺癌脊柱转移。
Int J Oncol. 2018 Oct;53(4):1544-1556. doi: 10.3892/ijo.2018.4487. Epub 2018 Jul 18.