School of Chemical and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Changzhou 213164, P. R. China.
Org Biomol Chem. 2021 Jan 28;19(3):619-626. doi: 10.1039/d0ob02383c.
A metal-free oxidative radical methylation/arylation of 2-arylbenzoimidazoles with DTBP as the oxidant and methyl radical source was developed. The reaction proceeds through a sequential methyl radical addition/cyclization pathway and affords a series of methyl functionalized benzimidazo[2,1-a]isoquinoline-6(5H)-ones in moderate to good yields. Besides, the ethylation/arylation of 2-arylbenzoimidazoles was also achieved with DTAP.
发展了一种无金属的氧化自由基甲基化/芳基化 2-芳基苯并咪唑的方法，以 DTBP 作为氧化剂和甲基自由基源。该反应通过连续的甲基自由基加成/环化途径进行，以中等至良好的收率得到一系列甲基化的苯并咪唑并[2,1-a]异喹啉-6(5H)-酮。此外，还可以使用 DTAP 实现 2-芳基苯并咪唑的乙基化/芳基化。
