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银催化脱羧自由基级联环化合成苯并咪唑并[2,1-a]异喹啉-6(5H)-酮。

Silver-catalyzed decarboxylative radical cascade cyclization toward benzimidazo[2,1-a]isoquinolin-6(5H)-ones.

机构信息

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.

出版信息

Chem Commun (Camb). 2019 Feb 28;55(19):2861-2864. doi: 10.1039/c8cc10243k.

DOI:10.1039/c8cc10243k
PMID:30761394
Abstract

A simple and efficient decarboxylative radical addition/cyclization strategy was developed, by which a wide range of benzimidazo[2,1-a]isoquinoline-6(5H)-ones were prepared in one-pot via reaction of functionalized 2-arylbenzoimidazoles and carboxylic acids in the presence of K2S2O8/AgNO3 under mild reaction conditions.

摘要

开发了一种简单高效的脱羧基自由基加成/环化策略，通过该策略，在温和的反应条件下，在 K2S2O8/AgNO3 的存在下，通过官能化的 2-芳基苯并咪唑和羧酸一锅反应，可制备得到广泛的苯并咪唑并[2,1-a]异喹啉-6(5H)-酮。

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