Kerkadi Abdelhamid, Lathief Shalima, Khial Yasmen, Teleb Toka, Attieh Grace, Rahman Md Mizanur, Shi Zumin, Agouni Abdelali
Department of Human Nutrition, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar.
Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.
Front Nutr. 2022 Apr 5;9:834007. doi: 10.3389/fnut.2022.834007. eCollection 2022.
Studies have reported inconsistent results for the relationship between body composition and bone mineral density (BMD) among women, especially those with a high rate of obesity. This study aims to examine the association between BMD and body composition among Qatari women. A cross-sectional study, using data from the Qatar Biobank (QBB), was conducted on 2,000 Qatari women aged 18 and over. Measurements were taken by dual-energy X-ray absorptiometry (DEXA) for body composition [visceral fat and android fat (AF)], gynoid fat (GF), trunk fat, total fat mass (TFM), total lean mass (LM) and bone mineral density (BMD), including the lumber spine, neck, femur and total body. The participants were divided into groups of normal and low BMD, based on their T-score. Non-linear regression analysis using the restricted cubic spline method was performed according to the T-score of the total BMD for the fat mass variables. Women with a low BMD (T-score <-1) had significantly lower body composition indicators. LM was positively correlated with BMD at the spine ( = 0.29, < 0.001), neck ( = 0.32, < 0.001), and femur ( = 0.28, < 0.001), as well as total BMD ( = 0.29, < 0.001) and T-score ( = 0.31, < 0.001), while the correlatio between TFM and BMD was negative and weak ( = -0.05, <0.017). Results of the non-linear regression indicated that components of fat distribution (TFM, AF, GF and trunk fat) were positively associated with total body T-score. In the adjusted non-liner regression, only a slight increase in T-score was recorded with an increase in FM. The association between FM and BMD was non-linear, suggesting that FM may not be a strong protector of bones among women with high rate of obesity.
研究报告称，女性尤其是肥胖率高的女性，其身体成分与骨密度（BMD）之间的关系结果并不一致。本研究旨在调查卡塔尔女性的骨密度与身体成分之间的关联。利用卡塔尔生物样本库（QBB）的数据进行了一项横断面研究，研究对象为2000名18岁及以上的卡塔尔女性。通过双能X线吸收法（DEXA）测量身体成分[内脏脂肪和男性化脂肪（AF）]、女性化脂肪（GF）、躯干脂肪、总脂肪量（TFM）、总瘦体重（LM）和骨密度（BMD），包括腰椎、颈部、股骨和全身。根据参与者的T值，将其分为骨密度正常组和低骨密度组。根据总骨密度的T值，对脂肪量变量采用受限立方样条法进行非线性回归分析。骨密度低（T值<-1）的女性身体成分指标显著较低。瘦体重与脊柱骨密度呈正相关（=0.29，<0.001）、颈部骨密度（=0.32，<0.001）、股骨骨密度（=0.28，<0.001）、总骨密度（=0.29，<0.001）和T值（=0.31，<0.001），而总脂肪量与骨密度之间的相关性为负且较弱（=-0.05，<0.017）。非线性回归结果表明，脂肪分布成分（总脂肪量、男性化脂肪、女性化脂肪和躯干脂肪）与全身T值呈正相关。在调整后的非线性回归中，随着脂肪量的增加，T值仅略有增加。脂肪量与骨密度之间的关联是非线性的，这表明在肥胖率高的女性中，脂肪量可能不是骨骼的有力保护因素。
