Department of Endocrinology and Metabolism, The Fourth People's Hospital of Shenyang, Shenyang 110031, Liaoning, China.
Center for Clinical Biological Samples, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning, China.
Contrast Media Mol Imaging. 2022 Apr 8;2022:6314435. doi: 10.1155/2022/6314435. eCollection 2022.
This study aims to investigate the effects of serum C-peptide levels on blood lipid and cardiovascular and cerebrovascular injury in patients with type 2 diabetes mellitus (T2DM).
China National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Web of Science, and Embase databases were searched for relevant studies published from January 2010 to June 2021. All retrieved randomized controlled trials that evaluated the effect of serum C-peptide levels on blood lipids or cardiovascular and cerebrovascular injuries in T2DM patients were included in our study. Patients in the included studies were divided into normal C-peptide group (control group) and low C-peptide group (treatment group) according to fasting C-peptide levels. Meta-analysis was performed using Stata16.0.
A total of 7 studies were included for the meta-analysis. Compared with the control group, the treatment group was associated with a higher incidence of coronary heart disease (OR = 4.89; 95% CI: 1.13, 21.24; < 0.05) and cerebral infarction (OR = 3.24; 95% CI: 0.59, 17.66; < 0.05). In addition, patients in the treatment group had significantly higher levels of total cholesterol (SMD = 0.01; 95% CI: -0.38, 0.39; < 0.05), triglyceride (SMD = 0.62; 95% CI: 0.24, 1.00; < 0.05), glycated hemoglobin (SMD = 0.25; 95% CI: -0.50, 1.00; < 0.05), and low-density lipoprotein cholesterol (SMD = 0.23; 95% CI: -0.00, 0.46; < 0.05). However, there was no significant difference in high-density lipoprotein cholesterol levels between the two groups (SMD = 0.30; 95% CI: -0.26, 0.86; > 0.05).
Low serum C-peptide level significantly increases the incidence of coronary heart disease and cerebral infarction. Additionally, low serum C-peptide increases blood lipid level and promotes lipid deposition. Collectively, low serum C-peptide has a negative impact on the occurrence and development of T2DM and therefore serum C-peptide level needs to be adjusted timely.
本研究旨在探讨血清 C 肽水平对 2 型糖尿病（T2DM）患者血脂及心脑血管损伤的影响。
检索中国知网（CNKI）、万方数据、PubMed、Web of Science、Embase 数据库，搜集 2010 年 1 月至 2021 年 6 月发表的关于血清 C 肽水平对 T2DM 患者血脂或心脑血管损伤影响的随机对照试验。根据空腹 C 肽水平，将纳入研究的患者分为正常 C 肽组（对照组）和低 C 肽组（治疗组）。采用 Stata16.0 进行 Meta 分析。
共纳入 7 项研究进行 Meta 分析。与对照组相比，治疗组冠心病（OR=4.89；95%CI：1.13，21.24； < 0.05）和脑梗死（OR=3.24；95%CI：0.59，17.66； < 0.05）的发生率更高。此外，治疗组患者总胆固醇（SMD=0.01；95%CI：-0.38，0.39； < 0.05）、三酰甘油（SMD=0.62；95%CI：0.24，1.00； < 0.05）、糖化血红蛋白（SMD=0.25；95%CI：-0.50，1.00； < 0.05）和低密度脂蛋白胆固醇（SMD=0.23；95%CI：-0.00，0.46； < 0.05）水平显著升高，高密度脂蛋白胆固醇水平差异无统计学意义（SMD=0.30；95%CI：-0.26，0.86； > 0.05）。
低血清 C 肽水平显著增加冠心病和脑梗死的发生率。此外，低血清 C 肽增加血脂水平，促进脂质沉积。综上，低血清 C 肽对 T2DM 的发生发展有不利影响，因此需要及时调整血清 C 肽水平。
