Czajor Julian, Abuillan Wasim, Nguyen Dinh Vu, Heidebrecht Christopher, Mondarte Evan A, Konovalov Oleg V, Hayashi Tomohiro, Felder-Flesch Delphine, Kaufmann Stefan, Tanaka Motomu
Physical Chemistry of Biosystems, Institute of Physical Chemistry, Heidelberg University 69120 Heidelberg Germany
Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), University of Strasbourg 23 rue du Loess 67034 Strasbourg France.
RSC Adv. 2021 May 17;11(29):17727-17733. doi: 10.1039/d1ra02571f. eCollection 2021 May 13.
Dendronized oligoethylene glycols (dendron OEGs) with two phosphonate groups (phosphonate ) have been drawing significant attention as a new class of coating materials for superparamagnetic iron oxide surfaces. However, despite dendron OEGs showing outstanding stability in physiological fluids in previous studies, little is understood about their structure and mechanical properties. Herein we report the surface and internal structures and mechanical properties of dendron OEGs, and quantitatively determine their ability to avoid non-specific adhesion of blood platelets. To gain insight into the interfacial force interactions, we measured the coarse-scale surface force acting on cell-sized particles and mapped the nanoscopic pinning centers by fast force mapping.
带有两个膦酸酯基团（膦酸酯）的树枝状低聚乙二醇（树枝状OEG）作为一类新型的超顺磁性氧化铁表面涂层材料受到了广泛关注。然而，尽管在先前的研究中树枝状OEG在生理流体中表现出出色的稳定性，但对其结构和力学性能却知之甚少。在此，我们报告了树枝状OEG的表面和内部结构以及力学性能，并定量测定了它们避免血小板非特异性粘附的能力。为了深入了解界面力相互作用，我们测量了作用在细胞大小颗粒上的粗粒度表面力，并通过快速力映射绘制了纳米级钉扎中心。
