Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Front Cell Infect Microbiol. 2022 Apr 11;12:881392. doi: 10.3389/fcimb.2022.881392. eCollection 2022.
Gonorrhea is a global health concern. Its etiological agent, , rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection. Attempts to generate an effective vaccine for gonorrhea have thus far been unsuccessful, as many structures on the bacterial envelope have the propensity to rapidly change, thus complicating recognition by the human immune system. In response to recent efforts from global health authorities to spur the efforts towards development of a vaccine, several new and promising steps have been made towards this goal, aided by advancements in computational epitope identification and prediction methods. Here, we provide a short review of recent progress towards a viable gonococcal vaccine, with a focus on antigen identification and characterization, and discuss a few of the tools that may be important in furthering these efforts.
淋病是一个全球性的健康问题。其病原体 ，迅速获得抗微生物药物耐药性，并且由于感染而不能产生保护性免疫。因此，迄今为止，试图为淋病生成有效的疫苗一直未能成功，因为细菌包膜上的许多结构都有迅速改变的倾向，从而使人类免疫系统难以识别。为了应对全球卫生当局最近为推动疫苗开发所做的努力，在计算表位鉴定和预测方法的帮助下，在朝着这一目标取得了一些新的、有希望的进展。在这里，我们提供了一个关于可行的淋球菌疫苗的最新进展的简短综述，重点是抗原的鉴定和特性，并讨论了一些可能对推进这些努力很重要的工具。
