Shi Hongyang, Zhang Yonghong, Wang Yu, Fang Ping, Liu Yun
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Oncol. 2023 Mar 14;13:1114218. doi: 10.3389/fonc.2023.1114218. eCollection 2023.
Our study aimed to explore the potential association of gene polymorphisms with lung cancer (LC) risk.
The five variants in were genotyped using Agena MassARRAY in 507 cases and 505 controls. Genetic models and haplotypes based on logistic regression analysis were used to evaluate the potential association between polymorphisms and LC susceptibility.
This study observed that rs12459936 was linked to an increased risk of LC in no-smoking participants (allele: OR = 1.38, = 0.035; homozygote: OR = 2.00, = 0.035; additive: OR = 1.40, = 0.034) and females (allele: OR = 1.64, = 0.002; homozygote: OR = 2.57, = 0.006; heterozygous: OR = 2.56, = 0.001; dominant: OR = 2.56, 0.002; additive: OR = 1.67, = 0.002). Adversely, there was a significantly decreased LC risk for rs3093110 in no-smoking participants (heterozygous: OR = 0.56, = 0.027; dominant: OR = 0.58, = 0.035), rs3093193 (allele: OR = 0.66, = 0.016; homozygote: OR = 0.33, = 0.011; recessive: OR = 0.38, = 0.021; additive: OR = 0.64, = 0.014), rs3093144 (recessive: OR = 0.20, = 0.045), and rs3093110 (allele: OR = 0.54, = 0.010; heterozygous: OR = 0.50, = 0.014; dominant: OR = 0.49, = 0.010; additive: OR = 0.54, = 0.011) in females.
The study demonstrated that variants were associated with LC susceptibility, with evidence suggesting that this connection may be affected by gender and smoking status.
我们的研究旨在探讨基因多态性与肺癌（LC）风险之间的潜在关联。
使用Agena MassARRAY对507例病例和505例对照中的五个变体进行基因分型。基于逻辑回归分析的遗传模型和单倍型用于评估多态性与LC易感性之间的潜在关联。
本研究观察到，rs12459936与不吸烟参与者患LC的风险增加有关（等位基因：OR = 1.38，P = 0.035；纯合子：OR = 2.00，P = 0.035；加性模型：OR = 1.40，P = 0.034）以及女性（等位基因：OR = 1.64，P = 0.002；纯合子：OR = 2.57，P = 0.006；杂合子：OR = 2.56，P = 0.001；显性模型：OR = 2.56，P = 0.002；加性模型：OR = 1.67，P = 0.002）。相反，对于rs3093110，不吸烟参与者患LC的风险显著降低（杂合子：OR = 0.56，P = 0.027；显性模型：OR = 0.58，P = 0.035），女性中rs3093193（等位基因：OR = 0.66，P = 0.016；纯合子：OR = 0.33，P = 0.011；隐性模型：OR = 0.38，P = 0.021；加性模型：OR = 0.64，P = 0.014）、rs3093144（隐性模型：OR = 0.20，P = 0.045）以及rs3093110（等位基因：OR = 0.54，P = 0.010；杂合子：OR = 0.50，P = 0.014；显性模型：OR = 0.49，P = 0.010；加性模型：OR = 0.54，P = 0.011）患LC的风险也显著降低。
该研究表明这些变体与LC易感性相关，有证据表明这种关联可能受性别和吸烟状况影响。
