Boruah Jayanta S, Devi Chayanika, Hazarika Upasana, Bhaskar Reddy P Vijaya, Chowdhury Devasish, Barthakur Manash, Kalita Pankaj
Material Nanochemistry Laboratory, Physical Sciences Division, Institute of Advanced Study in Science and Technology Paschim Boragaon, Garchuk Guwahati 781035 India
Department of Chemistry, Cotton University Assam India.
RSC Adv. 2021 Aug 19;11(45):28029-28041. doi: 10.1039/d1ra02669k. eCollection 2021 Aug 16.
Gold nanoparticles are one of the widely used metallic nanoparticle having unique surface plasmon characteristic, offers major utility in biomedical and therapeutic fields. However, chemically synthesized nanoparticle creates toxicity in the living organisms and contradicts the eco-friendly and cost-effective nature. So, developing greener synthetic route for synthesis of gold nanoparticle using natural materials is an enthralling field of research for its effectiveness in synthesizing eco-friendly, non-toxic materials. Moreover, biological components attached as stabilizing agent can exert its own effect along with the advantages of nanoparticle conjugation. In this work, we used for the first time methanolic leaf extract of as this fraction of exerts a neuroactive modulation against seizure as evidenced by earlier literature. The green gold nanoparticles synthesized were characterized by different characterization tools, dynamic light scattering and transmission electron microscopy techniques Prepared nanoparticles were biologically (antioxidant, antimicrobial and blood cytotoxicity) characterized to screen their further utility in therapeutic strategies. Characteristics and activities of green gold nanoparticles were compared with conventional citrate stabilized gold nanoparticles. It was observed that green gold nanoparticles prepared using show less cytotoxicity and helps in regeneration of neuronal cells in animal model study. It establishes the fact that conjugation of different plant extract fraction for stabilization of gold nanoparticle may be responsible factor for enhancement of bioactive nature of green gold nanoparticle. In addition, the green gold nanoparticle show efficient photo-catalytic efficiency. Development of such bioactive gold nanoparticles will lead to functional materials for biomedical and therapeutic applications.
金纳米颗粒是广泛使用的金属纳米颗粒之一，具有独特的表面等离子体特性，在生物医学和治疗领域具有重要用途。然而，化学合成的纳米颗粒会在生物体中产生毒性，与生态友好和成本效益的性质相矛盾。因此，利用天然材料开发更绿色的金纳米颗粒合成路线是一个引人入胜的研究领域，因为它在合成生态友好、无毒材料方面具有有效性。此外，作为稳定剂附着的生物成分在纳米颗粒共轭的优势之外还能发挥自身作用。在这项工作中，我们首次使用了[植物名称]的甲醇叶提取物，因为早期文献证明该植物的这一部分对癫痫具有神经活性调节作用。通过不同的表征工具、动态光散射和透射电子显微镜技术对合成的绿色金纳米颗粒进行了表征。对制备的纳米颗粒进行了生物学（抗氧化、抗菌和血液细胞毒性）表征，以筛选它们在治疗策略中的进一步用途。将绿色金纳米颗粒的特性和活性与传统柠檬酸盐稳定的金纳米颗粒进行了比较。观察到使用[植物名称]制备的绿色金纳米颗粒显示出较低的细胞毒性，并有助于动物模型研究中神经元细胞的再生。这证实了一个事实，即不同植物提取物部分共轭以稳定金纳米颗粒可能是增强绿色金纳米颗粒生物活性性质的原因。此外，绿色金纳米颗粒显示出高效的光催化效率。这种生物活性金纳米颗粒的开发将产生用于生物医学和治疗应用的功能材料。
