Liu Zhi, Ebadi Abdolghaffar, Toughani Mohsen, Mert Nihat, Vessally Esmail
School of Electrical and Automation Engineering, East China Jiaotong University Nanchang 330013 China
Department of Agriculture, Jouybar Branch, Islamic Azad University Jouybar Iran
RSC Adv. 2020 Oct 8;10(61):37299-37313. doi: 10.1039/d0ra04255b. eCollection 2020 Oct 7.
-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. There is therefore continuing interest in the development of novel and convenient protocols for the preparation of these pharmaceutically important compounds. Recently, direct sulfonamidation of (hetero)aromatic C-H bonds with easily available sulfonyl azides has emerged as an attractive and powerful strategy to access -(hetero)aryl sulfonamides where non-toxic nitrogen gas forms as the sole by-product. This review highlights recent advances and developments (2012-2020) in this fast growing research area with emphasis on the mechanistic features of the reactions.
芳基磺酰胺属于一类非常重要的有机硫化合物，在许多美国食品药品监督管理局（FDA）批准的药物中都有发现，如多非利特、决奈达隆、伊布利特、索他洛尔、磺胺嘧啶、磺胺甲噻二唑、维莫非尼等等。因此，人们一直对开发新颖便捷的方法来制备这些具有药物重要性的化合物感兴趣。最近，利用易于获得的磺酰叠氮化物对（杂）芳族C-H键进行直接磺酰胺化反应，已成为一种有吸引力且强大的策略，可用于制备芳基（杂芳基）磺酰胺，该反应以无毒氮气作为唯一副产物生成。本综述重点介绍了这一快速发展的研究领域（2012年至2020年）的最新进展和发展情况，并着重阐述了反应的机理特征。
