Landini Nicholas, Orlandi Martina, Occhipinti Mariaelena, Nardi Cosimo, Tofani Lorenzo, Bellando-Randone Silvia, Ciet Pierluigi, Wielopolski Piotr, Benkert Thomas, Bruni Cosimo, Bertolo Silvia, Moggi-Pignone Alberto, Matucci-Cerinic Marco, Morana Giovanni, Colagrande Stefano
Department of Radiology, Ca' Foncello General Hospital, Treviso.
Department of Experimental and Clinical Biomedical Sciences, University of Florence & Radiodiagnostic Unit n. 2 AOUC.
J Thorac Imaging. 2023 Mar 1;38(2):97-103. doi: 10.1097/RTI.0000000000000637. Epub 2022 Feb 4.
To test respiratory-triggered ultrashort echo-time (UTE) Spiral VIBE-MRI sequence in systemic sclerosis-interstitial lung disease assessment compared with computed tomography (CT).
Fifty four SSc patients underwent chest CT and UTE (1.5 T). Two radiologists, independently and in consensus, verified ILD presence/absence and performed a semiquantitative analysis (sQA) of ILD, ground-glass opacities (GGO), reticulations and honeycombing (HC) extents on both scans. A CT software quantitative texture analysis (QA) was also performed. For ILD detection, intra-/inter-reader agreements were computed with Cohen K coefficient. UTE sensitivity and specificity were assessed. For extent assessments, intra-/inter-reader agreements and UTE performance against CT were computed by Lin's concordance coefficient (CCC).
Three UTE were discarded for low quality, 51 subjects were included in the study. Of them, 42 QA segmentations were accepted. ILD was diagnosed in 39/51 CT. UTE intra-/inter-reader K in ILD diagnosis were 0.56 and 0.26. UTE showed 92.8% sensitivity and 75.0% specificity. ILD, GGO, and reticulation extents were 14.8%, 7.7%, and 7.1% on CT sQA and 13.0%, 11.2%, and 1.6% on CT QA. HC was <1% and not further considered. UTE intra-/inter-reader CCC were 0.92 and 0.89 for ILD extent and 0.84 and 0.79 for GGO extent. UTE RET extent intra-/inter-reader CCC were 0.22 and 0.18. UTE ILD and GGO extents CCC against CT sQA and QA were ≥0.93 and ≥0.88, respectively. RET extent CCC were 0.35 and 0.22 against sQA and QA, respectively.
UTE Spiral VIBE-MRI sequence is reliable in assessing ILD and GGO extents in systemic sclerosis-interstitial lung disease patients.
与计算机断层扫描（CT）相比，测试呼吸触发的超短回波时间（UTE）螺旋VIBE-MRI序列在系统性硬化症-间质性肺病评估中的应用。
54例系统性硬化症（SSc）患者接受了胸部CT和UTE（1.5T）检查。两名放射科医生独立且一致地核实间质性肺病（ILD）的有无，并对两次扫描上的ILD、磨玻璃影（GGO）、网状影和蜂窝状改变（HC）范围进行半定量分析（sQA）。还进行了CT软件定量纹理分析（QA）。对于ILD检测，使用Cohen K系数计算阅片者内/间一致性。评估UTE的敏感性和特异性。对于范围评估，通过Lin一致性系数（CCC）计算阅片者内/间一致性以及UTE相对于CT的性能。
3例UTE因质量低被排除，51名受试者纳入研究。其中，42次QA分割被接受。51例患者中39例CT诊断为ILD。UTE在ILD诊断中的阅片者内/间K值分别为0.56和0.26。UTE的敏感性为92.8%，特异性为75.0%。CT的sQA上ILD、GGO和网状影范围分别为14.8%、7.7%和7.1%，CT的QA上分别为13.0%、11.2%和1.6%。HC<1%，未进一步考虑。UTE在ILD范围的阅片者内/间CCC分别为0.92和0.89，GGO范围的分别为0.84和0.79。UTE网状影范围的阅片者内/间CCC分别为0.22和0.18。UTE的ILD和GGO范围相对于CT的sQA和QA的CCC分别≥0.93和≥0.88。网状影范围相对于sQA和QA的CCC分别为0.35和0.22。
UTE螺旋VIBE-MRI序列在评估系统性硬化症-间质性肺病患者的ILD和GGO范围方面是可靠的。
