Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
Cephalalgia. 2011 Jan;31(1):6-12. doi: 10.1177/0333102410365108. Epub 2010 Apr 7.
To determine if migraineurs have evidence of interictal cutaneous sensitisation.
Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured.
Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls.
Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
确定偏头痛患者是否存在发作间期皮肤敏化的证据。
比较 20 例发作性偏头痛患者、20 例慢性偏头痛患者和 20 名非偏头痛对照受试者的热痛和机械痛阈值。当受试者至少 48 小时无偏头痛发作时进行定量感觉测试。测量热、冷痛阈值和热、冷痛耐受阈值。
头痛组的热痛阈值和热痛耐受阈值差异有统计学意义（P=0.001）。在发作间期，发作性和慢性偏头痛患者对热刺激比非偏头痛对照组更敏感。
发作间期敏化可能使偏头痛患者容易发生头痛，可能是偏头痛活动的标志物，也是治疗的靶点。
