发作性和慢性偏头痛患者在偏头痛发作之间对热刺激敏感。
Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks.
机构信息
Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
出版信息
Cephalalgia. 2011 Jan;31(1):6-12. doi: 10.1177/0333102410365108. Epub 2010 Apr 7.
Abstract
OBJECTIVE
To determine if migraineurs have evidence of interictal cutaneous sensitisation.
SUBJECTS AND METHODS
Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured.
RESULTS
Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls.
CONCLUSIONS
Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
摘要
目的
确定偏头痛患者是否存在发作间期皮肤敏化的证据。
受试者和方法
比较 20 例发作性偏头痛患者、20 例慢性偏头痛患者和 20 名非偏头痛对照受试者的热痛和机械痛阈值。当受试者至少 48 小时无偏头痛发作时进行定量感觉测试。测量热、冷痛阈值和热、冷痛耐受阈值。
结果
头痛组的热痛阈值和热痛耐受阈值差异有统计学意义（P=0.001）。在发作间期，发作性和慢性偏头痛患者对热刺激比非偏头痛对照组更敏感。
结论
发作间期敏化可能使偏头痛患者容易发生头痛，可能是偏头痛活动的标志物，也是治疗的靶点。
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1
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Cephalalgia. 2009 Oct;29(10):1042-8. doi: 10.1111/j.1468-2982.2008.01834.x. Epub 2009 Mar 12.
2
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3
Evidence of persistent central sensitization in chronic headaches: a multi-method study.慢性头痛中持续性中枢敏化的证据：一项多方法研究。
J Headache Pain. 2008 Oct;9(5):295-300. doi: 10.1007/s10194-008-0061-7. Epub 2008 Aug 9.
4
Prevalence and characteristics of allodynia in headache sufferers: a population study.头痛患者中异常性疼痛的患病率及特征：一项人群研究。
Neurology. 2008 Apr 22;70(17):1525-33. doi: 10.1212/01.wnl.0000310645.31020.b1.
5
Acute and interictal allodynia in patients with different headache forms: an Italian pilot study.不同头痛形式患者的急性和发作间期痛觉过敏：一项意大利的初步研究。
Headache. 2008 Feb;48(2):272-7. doi: 10.1111/j.1526-4610.2007.00998.x. Epub 2007 Dec 11.
6
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Ann Neurol. 2008 Feb;63(2):148-58. doi: 10.1002/ana.21211.
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9
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10
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