Environmental Health Engineering Department, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
Biodegradation. 2022 Jun;33(3):267-281. doi: 10.1007/s10532-022-09979-w. Epub 2022 Apr 28.
Drug compounds are one of the main contributors to the entry of micro-pollutants into the environment, known as a constant threat to environmental stability. Atenolol is a type of beta-blocker extensively used to cure cardiovascular disorders. The residues of this compound have been continuously detected in aquatic environments because it is a polar and poorly biodegradable compound. Thus, removing atenolol from wastewater is essential before discharging into the environment. Biological processes are considered the most important removal process for polar drugs in wastewater treatment plants. Accordingly, for the first time in this study, the SBR performance was investigated in the biodegradation and mineralization of atenolol under different concentrations (50-600 mg/L) and hydraulic retention times (48-32 h). Based on the results, the time required for the acclimation of biomass to atenolol (C: 50 mg/L and the HRT: 48 h) was 80 days. The SBR efficiencies under optimum conditions (C: 400 mg/L and HRT: 40 h) in removing the atenolol and COD were 91% and 87%, respectively. For the first time in this study, one of the main pathways of the atenolol biodegradation was identified. Based on the review and comparison of the results of this study with existing literature showing that the SBR used in this study was able to remove higher concentrations with better efficiencies than other processes. Therefore, it can be concluded that the SBR used in this study could be considered an efficient and promising technique for treating wastewaters containing atenolol and other beta-blocker group drugs.
药物化合物是导致环境中微污染物进入的主要因素之一，被认为是对环境稳定性的持续威胁。阿替洛尔是一种广泛用于治疗心血管疾病的β受体阻滞剂。由于它是一种极性和生物降解性差的化合物，因此该化合物的残留一直在水生环境中被检测到。因此，在排入环境之前，从废水中去除阿替洛尔至关重要。生物过程被认为是污水处理厂中极性药物最重要的去除过程。因此，在这项研究中，首次研究了 SBR 在不同浓度（50-600mg/L）和水力停留时间（48-32h）下对阿替洛尔的生物降解和矿化作用的性能。根据结果，生物量对阿替洛尔（C：50mg/L 和 HRT：48h）的适应时间为 80 天。在最佳条件（C：400mg/L 和 HRT：40h）下，SBR 去除阿替洛尔和 COD 的效率分别为 91%和 87%。在这项研究中，首次确定了阿替洛尔生物降解的主要途径之一。通过对本研究结果与现有文献的回顾和比较表明，本研究中使用的 SBR 能够以比其他工艺更好的效率去除更高浓度的药物。因此，可以得出结论，本研究中使用的 SBR 可以被认为是一种处理含有阿替洛尔和其他β受体阻滞剂类药物的废水的有效且有前途的技术。
