Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Life Sci. 2022 Jul 1;300:120582. doi: 10.1016/j.lfs.2022.120582. Epub 2022 Apr 26.
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a promising natural compound in the treatment of diseases. Its diverse pharmacological effects with limited side effects have promoted researchers to pursue new therapeutic applications. It has little affinity for classical cannabinoid receptors (CB1 and CB2). Considering this and its diverse pharmacological effects, it is logical to set up studies for finding its putative potential targets other than CB1 and CB2. A class of ion channels, namely transient potential channels (TRP), has been identified during two recent decades. More than 30 members of this family have been studied, so far. They mediate diverse physiological functions and are associated with various pathological conditions. Some have been recognized as key targets for natural compounds such as capsaicin, menthol, and CBD. Studies show that CBD has agonistic effects for TRPV1-4 and TRPA1 channels with antagonistic effects on the TRPM8 channel. In this article, we reviewed the recent findings considering the interaction of CBD with these channels. The review indicated that TRP channels mediate, at least in part, the effects of CBD on seizure, inflammation, cancer, pain, acne, and vasorelaxation. This highlights the role of TRP channels in CBD-mediated effects, and binding to these channels may justify part of its paradoxical effects in comparison to classical phytocannabinoids.
大麻二酚 (CBD) 作为大麻中的主要植物大麻素，已成为治疗疾病的有前途的天然化合物。其具有有限副作用的多种药理学作用促使研究人员寻求新的治疗应用。它与经典的大麻素受体 (CB1 和 CB2) 亲和力低。考虑到这一点及其多种药理学作用，有理由对除 CB1 和 CB2 以外的 CBD 的潜在靶点进行研究。最近二十年，人们已经鉴定出一类离子通道，即瞬时电位通道 (TRP)。到目前为止，已经研究了该家族的 30 多个成员。它们介导多种生理功能，并与各种病理状况相关。一些已经被认为是天然化合物（如辣椒素、薄荷醇和 CBD）的关键靶点。研究表明，CBD 对 TRPV1-4 和 TRPA1 通道具有激动作用，对 TRPM8 通道具有拮抗作用。在本文中，我们综述了最近关于 CBD 与这些通道相互作用的研究结果。该综述表明，TRP 通道至少部分介导了 CBD 对癫痫发作、炎症、癌症、疼痛、痤疮和血管舒张的作用。这突出了 TRP 通道在 CBD 介导的作用中的作用，并且与这些通道的结合可能解释了与经典植物大麻素相比，CBD 的部分矛盾作用。
