Nouwen E J, Hendrix P G, Dauwe S, Eerdekens M W, De Broe M E
Am J Pathol. 1987 Feb;126(2):230-42.
The incidence and histologic characteristics of the expression of placental alkaline phosphatase (PLAP) in ovarian tumors was compared with that of five other tumor antigens. Three monoclonal antibodies were used for the specific localization of PLAP. PLAP was present in some sex cord cells of the 13-16-week fetal ovary, probably germ cells. In normal ovaries, all antigens except carcinoembryonic antigen (CEA) were frequently found in inclusion cysts; the germinal epithelium was positive only for cancer antigen 125 (CA 125). The frequency and extent of PLAP expression in nonmucinous carcinomas was higher than observed for CA 19-9 and CEA, but was lower than for CA 125 and human milk fat globule antigen. Serous tumors had the highest PLAP expression, followed by endometrioid and poorly differentiated adenocarcinomas, and some other tumors. PLAP was predominantly membranous; its histologic distribution was in general heterogeneous. Different antibodies to PLAP gave different staining intensities in some tumors, but the staining patterns were always qualitatively identical.
将卵巢肿瘤中胎盘碱性磷酸酶（PLAP）表达的发生率及组织学特征与其他五种肿瘤抗原进行了比较。使用三种单克隆抗体对PLAP进行特异性定位。PLAP存在于13 - 16周胎儿卵巢的一些性索细胞中，可能是生殖细胞。在正常卵巢中，除癌胚抗原（CEA）外，所有抗原在包涵囊肿中均常见；生发上皮仅对癌抗原125（CA 125）呈阳性。非黏液性癌中PLAP表达的频率和程度高于CA 19 - 9和CEA，但低于CA 125和人乳脂肪球抗原。浆液性肿瘤的PLAP表达最高，其次是子宫内膜样癌和低分化腺癌以及其他一些肿瘤。PLAP主要位于细胞膜；其组织学分布总体上不均匀。针对PLAP的不同抗体在某些肿瘤中给出不同的染色强度，但染色模式在质量上总是相同的。
