Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
BMC Pharmacol Toxicol. 2022 Apr 28;23(1):28. doi: 10.1186/s40360-022-00567-5.
The use of chemical pesticides in developing countries like Bangladesh and their impacts on human health and food security is a global concern. Bangladesh is an agricultural dependent country for the growing population demand for food security and food safety. We conduct this study to assess public health threats of commonly utilised pesticides including malathion and nitrobenzene in female rabbit model.
Thirty New Zealand White healthy rabbit was divided randomly into three groups; and subjected to distilled water as control, malathion@ 5 mg/kg body weight and nitrobenzene@ 5 mg/kg body i.p daily for the next 15 days. Hematology, serum biochemistry and hormonal assay were performed.
Red blood cell (RBC) concentrations (TEC, Hb, PCV%) were reduced in rabbits exposed to malathion and nitrobenzene. The neutrophil and eosinophil percentage were increased in the malathion and nitrobenzene exposed juvenile rabbit group. We found that serum aspartate aminotransferase (AST) and creatinine were increased in the nitrobenzene exposed group in infants, whereas malathion exposure increased serum alanine aminotransferase (ALT). In contrast, the juvenile group exposed to malathion increased the ALT level. There was no change in AST or creatinine levels in juvenile rabbits exposed to malathion or nitrobenzene. Serum estradiol levels were significantly lower in rabbits exposed to malathion and nitrobenzene. Serum testosterone concentration was increased in juvenile rabbits exposed to malathion and nitrobenzene, but progesterone was decreased in malathion exposed juvenile rabbits.
However, this study highlights the importance of rigorous monitoring and testing of agricultural products. In addition, strengthen research and extension in the fields of agro economy, organic farming, local universities and farmer associations.
在孟加拉国等发展中国家使用化学农药及其对人类健康和食品安全的影响是一个全球性的问题。孟加拉国是一个农业依赖型国家，随着人口对粮食安全和食品安全需求的增长。我们进行这项研究是为了评估在雌性兔模型中常用农药（马拉硫磷和硝基苯）对公共健康的威胁。
将 30 只新西兰白兔随机分为三组；并分别给予蒸馏水作为对照，马拉硫磷 5mg/kg 体重和硝基苯 5mg/kg 体重，每日腹腔注射，共 15 天。进行血液学、血清生化和激素检测。
暴露于马拉硫磷和硝基苯的兔子红细胞（RBC）浓度（TEC、Hb、PCV%）降低。中性粒细胞和嗜酸性粒细胞百分比在暴露于马拉硫磷和硝基苯的幼兔组中增加。我们发现，暴露于硝基苯的幼兔血清天冬氨酸转氨酶（AST）和肌酐升高，而暴露于马拉硫磷的幼兔血清丙氨酸转氨酶（ALT）升高。相比之下，暴露于马拉硫磷的幼兔组 ALT 水平升高。暴露于马拉硫磷或硝基苯的幼兔血清 AST 或肌酐水平无变化。暴露于马拉硫磷和硝基苯的兔子血清雌二醇水平明显降低。暴露于马拉硫磷和硝基苯的幼兔血清睾丸酮浓度升高，但暴露于马拉硫磷的幼兔孕酮浓度降低。
然而，这项研究强调了对农业产品进行严格监测和测试的重要性。此外，加强农业经济、有机农业、地方大学和农民协会等领域的研究和推广。
