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局灶性癫痫发作时意识检测:临床实践及现行指南解读。

Testing awareness in focal seizures: Clinical practice and interpretation of current guidelines.

机构信息

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.

Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Ann Clin Transl Neurol. 2022 May;9(5):762-765. doi: 10.1002/acn3.51552. Epub 2022 Apr 29.

DOI:10.1002/acn3.51552
PMID:35485201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9082375/
Abstract

The International League Against Epilepsy (ILAE) classification of focal seizures uses recall of experiences post-ictally to assess for awareness and not ictal responsiveness to external stimuli, stating that responsiveness is often not tested. We investigated how clinicians assess for seizure awareness by administering an online survey. We found that most respondents use both responsiveness and recall to assess for awareness in the clinic (78%) and in the epilepsy monitoring unit (72%). Furthermore, 60% of respondents believe that the ILAE recommends using both measures. Given our results, we believe that using both responsiveness and recall would provide a more practical classification of impaired consciousness in focal seizures.

摘要

国际抗癫痫联盟(ILAE)的局灶性癫痫发作分类使用发作后对经历的回忆来评估意识,而不是对外界刺激的发作反应,称反应通常未被测试。我们通过在线调查研究了临床医生如何评估癫痫发作意识。我们发现,大多数受访者在诊所(78%)和癫痫监测单元(72%)中都使用反应和回忆来评估意识。此外,60%的受访者认为 ILAE 建议使用这两种方法。鉴于我们的结果,我们认为同时使用反应和回忆可以更实际地对局灶性癫痫发作中的意识障碍进行分类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cd/9082375/94fe322572f9/ACN3-9-762-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cd/9082375/94fe322572f9/ACN3-9-762-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3cd/9082375/94fe322572f9/ACN3-9-762-g001.jpg

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本文引用的文献

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Ann Clin Transl Neurol. 2022 Jan;9(1):16-29. doi: 10.1002/acn3.51485. Epub 2022 Jan 11.
2
Investigation of patient and observer agreement on description of seizures at initial clinical visit.在初次临床就诊时,对患者和观察者在描述癫痫发作方面的一致性进行调查。
Ann Clin Transl Neurol. 2019 Dec;6(12):2601-2606. doi: 10.1002/acn3.50950. Epub 2019 Dec 5.
3
Instruction manual for the ILAE 2017 operational classification of seizure types.
在意识受损的局灶性癫痫发作小鼠模型中,慢波和快波皮质胆碱能觉醒降低。
Cell Rep. 2024 Dec 24;43(12):115012. doi: 10.1016/j.celrep.2024.115012. Epub 2024 Dec 5.
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Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch.使用可穿戴技术进行癫痫自动反应性测试:ARTiE手表
Epilepsia. 2025 Jan;66(1):104-116. doi: 10.1111/epi.18181. Epub 2024 Nov 19.
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Novel KCNQ2 missense variant expands the genotype spectrum of DEE7.新型 KCNQ2 错义变异扩展了 DEE7 的基因型谱。
Neurol Sci. 2024 Nov;45(11):5481-5488. doi: 10.1007/s10072-024-07655-w. Epub 2024 Jun 17.
6
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing.评估局灶性癫痫发作期间的意识和意识:反应性测试与回忆测试。
Epileptic Disord. 2022 Oct 1;24(5):899-905. doi: 10.1684/epd.2022.1472.
国际抗癫痫联盟(ILAE)2017年癫痫发作类型操作分类指南
Epilepsia. 2017 Apr;58(4):531-542. doi: 10.1111/epi.13671. Epub 2017 Mar 8.
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