Department of Endocrinology and Metabolic Diseases, Dokuz Eylul University Hospital, Balcova, İzmir, Turkey.
Vocational School of Healthcare, Dokuz Eylul University, Balçova, İzmir, Turkey.
Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1223-1229. doi: 10.31557/APJCP.2022.23.4.1223.
BACKGROUND/AIM: Epidemiological studies indicate that the risk of several types of cancer is high in diabetic patients. The aim of this study is to evaluate the association between diabetes and diabetes related cancers in a cohort design.
The baseline survey was conducted as a community screening programme from 2007 to 2009 in a population over 30 years of age. Diabetes definition was based on fasting blood glucose level ≥ 126 mg/dl and self-reported diabetes history. Data on incident cancer cases and pathological types were obtained from the İzmir Cancer Registry between 2007-2013. Odds ratios (OR) were estimated for the relationship between diabetes and diabetes-related cancer types for men and women separately and adjusted for BMI and age. Odds Ratio and 95% confidence intervals were calculated using logistic regression models in IBM SPSS Statistics 24.0.
Data from 10,375 women (65.4%) and 5,494 men (34.6%) who did not declare any cancer in 2007 were evaluated. The cumulative incidence of diabetes related cancers was 2,293 per 100,000 in men and 1,455 per 100,000 in women. Total diabetes related cancer incidence was higher in diabetics (3,770 per 100,000) than nondiabetics (2,109 per 100,000) in men.
There was no statistically significant association between diabetes and cancers. The analyses can be repeated in the future when the cohort gets older and more incident cases of cancers occur.
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背景/目的：流行病学研究表明，糖尿病患者患多种癌症的风险较高。本研究旨在通过队列设计评估糖尿病与糖尿病相关癌症之间的关联。
基线调查作为 2007 年至 2009 年在 30 岁以上人群中进行的社区筛查计划进行。糖尿病的定义基于空腹血糖水平≥126mg/dl 和自我报告的糖尿病病史。2007-2013 年间，从伊兹密尔癌症登记处获得了癌症病例和病理类型的数据。使用 IBM SPSS Statistics 24.0 中的逻辑回归模型，分别为男性和女性计算了糖尿病与糖尿病相关癌症类型之间的比值比（OR），并调整了 BMI 和年龄。计算了比值比和 95%置信区间。
评估了 10375 名女性（65.4%）和 5494 名男性（34.6%）在 2007 年未报告任何癌症的人群数据。男性糖尿病相关癌症的累积发病率为每 100,000 人 2293 人，女性为每 100,000 人 1455 人。男性糖尿病患者的总糖尿病相关癌症发病率（每 100,000 人 3770 人）高于非糖尿病患者（每 100,000 人 2109 人）。
糖尿病与癌症之间没有统计学显著关联。当队列年龄更大且癌症的发生率更高时，可以在未来重复分析。
