Department of Dermatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Med Mol Morphol. 2022 Sep;55(3):210-226. doi: 10.1007/s00795-022-00320-1. Epub 2022 Apr 29.
Female pattern hair loss (FPHL), a type of hair disease common in pre- and postmenopausal women, is characterized by thinning of hair to O-type, mainly at the crown. Although a mouse model of this disease has recently been established, its details are still unknown, and thus, warrants further analysis. In this study, 3 week-old and 7- to 8 week-old C57BL/6 female mice were divided into two groups: one group underwent ovariectomy (OVX), while the other underwent sham surgery. In the 3 week-old mice, the dorsal skin was collected at seven weeks of age, while in the 7- to 8 week-old mice, it was collected at 12 and 24 weeks of age. In the former group, both the pore size of the hair follicles (HFs) and diameter of the hair shaft of telogen HFs decreased upon OVX; while in the latter group, these factors increased significantly. Notably, the thickness of the dermis and subcutis increased significantly in the OVX group. It needs to be further elucidated whether OVX mouse could serve as an ideal mouse model for FPHL, but our results upon evaluation of skin thickness indicate that it could be used to establish a novel treatment for non-hair-related diseases, such as post-menopause-related skin condition.
女性型脱发（FPHL）是一种常见于绝经前和绝经后妇女的毛发疾病，其特征是毛发变细呈 O 型，主要在头顶。虽然最近已经建立了这种疾病的小鼠模型，但它的细节仍不清楚，因此需要进一步分析。在这项研究中，3 周龄和 7-8 周龄的 C57BL/6 雌性小鼠分为两组：一组接受卵巢切除术（OVX），另一组接受假手术。在 3 周龄小鼠中，背部皮肤在 7 周龄时采集，而在 7-8 周龄小鼠中，在 12 周龄和 24 周龄时采集。在前一组中，OVX 后生长期毛囊的毛孔大小和毛干直径均减小；在后一组中，这些因素显著增加。值得注意的是，OVX 组的真皮和皮下组织厚度显著增加。还需要进一步阐明 OVX 小鼠是否可以作为 FPHL 的理想小鼠模型，但我们对皮肤厚度的评估结果表明，它可以用于建立一种治疗非毛发相关疾病的新方法，如绝经后相关皮肤状况。
