Zheng Lin, Wei Fang, Li Guolin
Center for Biomedical Aging, National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, P. R. China.
Key Laboratory of Hunan Province for Model Animal and Stem Cell Biology, School of Medicine, Hunan Normal University, Changsha, Human, 410081, P. R. China.
J Microbiol. 2022 May;60(5):451-460. doi: 10.1007/s12275-022-2009-z. Epub 2022 Apr 29.
Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host autophagy system to recognize and eliminate invading bacteria are complex, and vary according to different pathogens. Although both ubiquitin-dependent and ubiquitin-independent autophagy exist in host to defense invading bacteria, successful pathogens have evolved diverse strategies to escape from or paralyze host autophagy system. In this review, we discuss the mechanisms of host autophagy system to recognize and eliminate intracellular pathogens and the mechanisms of different pathogens to escape from or paralyze host autophagy system, with a particular focus on the most extensively studied bacteria.
异噬作用是一种用于清除细胞内细菌的特异性选择性自噬。目前的证据表明，宿主自噬系统识别和清除入侵细菌的过程很复杂，并且因不同病原体而异。尽管宿主中存在依赖泛素和不依赖泛素的自噬来抵御入侵细菌，但成功的病原体已经进化出多种策略来逃避或麻痹宿主自噬系统。在这篇综述中，我们讨论了宿主自噬系统识别和清除细胞内病原体的机制以及不同病原体逃避或麻痹宿主自噬系统的机制，特别关注研究最广泛的细菌。
