Department of Neurobiology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China.
High Alt Med Biol. 2022 Sep;23(3):273-283. doi: 10.1089/ham.2021.0166. Epub 2022 Apr 29.
Zhang, Guangbo, Yanzhao Zhou, Zhengtao Cao, Xiang Cheng, Xiangpei Yue, Tong Zhao, Ming Zhao, Yongqi Zhao, Ming Fan, and Lingling Zhu. Preliminary intermittent hypoxia training alleviates the damage of sustained normobaric hypoxia on human hematological indexes and cerebral white matter. . 23:273-283, 2022. We aimed to examine the effects of preliminary intermittent hypoxia training (IHT) on human hematological indexes and cerebral white matter (WM) after exposure to a simulated altitude of 4,300 m. We recruited 20 young healthy volunteers. Participants were then randomized to either the IHT group ( = 10) or the control group ( = 10). We measured the physiological function of the control group at sea level and after exposure to a simulated altitude of 4,300 m, respectively. The IHT group performed the above tests at three time points: before and after hypoxia training, and after exposure to a simulated altitude of 4,300 m, respectively. We found that mean SpO during day 10 of hypoxia training showed a significant increase compared with mean SpO on day 1 (88.3% ± 1.5% vs. 90.0% ± 1.6%, < 0.05), and erythrocyte P of post-training was significantly increased compared with pretraining (37.8 ± 2.9 mmHg vs. 45.9 ± 6.4 mmHg, < 0.05). Mean SpO measures after acute exposure to high altitude exhibited a significant difference, with the IHT group showing significantly greater SpO than the control group (73.8% ± 3.7% vs. 77.4% ± 3.2%, < 0.05), and the Lake Louise Score was also lower than the control group (2.55 ± 2.1 vs. 6.67 ± 2.5, < 0.05). After daily IHT, brain-derived neurotrophic factor plasma levels of participants in the IHT group did not change but significantly increased in response to high-altitude hypoxia (103.5% ± 70.4% vs. 29.7% ± 73.2%, < 0.05). Interleukin-10 (IL-10) plasma level did not change before and after IHT in the IHT group, whereas the IL-10 plasma level of the control group after high-altitude exposure was significantly higher. Furthermore, we found that fractional anisotropy values in the left corticospinal tract and splenium of the corpus callosum in the IHT group were significantly higher than those in the control group after high-altitude hypoxia. These results demonstrate that IHT alleviates the damage of sustained normobaric hypoxia on human hematological indexes and cerebral WM.
张光博、周延昭、曹正涛、程相、岳向培、赵彤、赵明、赵勇奇、范明、朱玲玲。初步间歇性低氧训练可减轻持续常压低氧对人体血液学指标和脑白质的损害。23:273-283，2022。我们旨在研究初步间歇性低氧训练（IHT）对暴露于模拟海拔 4300 米后人体血液学指标和脑白质（WM）的影响。我们招募了 20 名年轻健康的志愿者。然后，参与者被随机分为 IHT 组（n=10）和对照组（n=10）。我们分别在海平面和暴露于模拟海拔 4300 米后测量对照组的生理功能。IHT 组在三个时间点进行了上述测试：分别在低氧训练前、后和暴露于模拟海拔 4300 米后。我们发现，低氧训练第 10 天的平均 SpO 与第 1 天的平均 SpO 相比显著增加（88.3%±1.5%比 90.0%±1.6%， < 0.05），且训练后的红细胞 P 较训练前显著增加（37.8±2.9mmHg 比 45.9±6.4mmHg， < 0.05）。急性暴露于高海拔后的平均 SpO 测量值存在显著差异，IHT 组的 SpO 显著大于对照组（73.8%±3.7%比 77.4%±3.2%， < 0.05），且路易丝湖评分也低于对照组（2.55±2.1 比 6.67±2.5， < 0.05）。每天进行 IHT 后，IHT 组参与者的脑源性神经营养因子血浆水平没有变化，但对高海拔缺氧的反应显著增加（103.5%±70.4%比 29.7%±73.2%， < 0.05）。IHT 组 IHT 前后白细胞介素-10（IL-10）血浆水平没有变化，而对照组暴露于高海拔后的 IL-10 血浆水平显著升高。此外，我们发现 IHT 组在高海拔缺氧后左侧皮质脊髓束和胼胝体压部的各向异性分数值明显高于对照组。这些结果表明，IHT 可减轻持续常压低氧对人体血液学指标和脑 WM 的损害。
