Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Development Coordination Office, Beijing Xiaotangshan Hospital, Beijing, China.
CNS Neurosci Ther. 2024 Mar;30(3):e14662. doi: 10.1111/cns.14662.
Intermittent hypoxia (IH) is emerging as a cost-effective nonpharmacological method for vital organ protection. We aimed to assess the effects of a short-term moderate intermittent hypoxia preconditioning protocol (four cycles of 13% hypoxia lasting for 10 min with 5-min normoxia intervals) on acute hypoxic injury induced by sustained hypoxic exposure (oxygen concentration of 11.8% for 6 h).
One hundred healthy volunteers were recruited and randomized to the IH group and the control group to receive IH or sham-IH preconditioning for 5 days, respectively, and then were sent to a hypoxic chamber for simulated acute high-altitude exposure (4500 m).
The overall incidence of acute mountain sickness was 27% (27/100), with 14% (7/50) in the IH group and 40% (20/50) in the control group (p = 0.003). After 6-h simulated high-altitude exposure, the mean Lake Louise Score was lower in the IH group as compared to controls (1.30 ± 1.27 vs. 2.04 ± 1.89, p = 0.024). Mean peripheral oxygen saturations (SpO ) and intracranial pressure (ICP) measures after acute hypoxic exposure exhibited significant differences, with the IH group showing significantly greater SpO values (85.47 ± 5.14 vs. 83.10 ± 5.15%, p = 0.026) and lower ICP levels than the control group (115.59 ± 32.15 vs. 130.36 ± 33.83 mmH O, p = 0.028). IH preconditioning also showed greater effects on serum protein gene product 9.5 (3.89 vs. 29.16 pg/mL; p = 0.048) and C-reactive protein (-0.28 vs. 0.41 mg/L; p = 0.023).
The short-term moderate IH improved the tolerance to hypoxia and exerted protection against acute hypoxic injury induced by exposure to sustained normobaric hypoxia, which provided a novel method and randomized controlled trial evidence to develop treatments for hypoxia-related disease.
间歇性低氧（IH）作为一种具有成本效益的非药物方法，正在成为重要器官保护的研究热点。本研究旨在评估短期中度间歇性低氧预处理方案（4 个周期，每个周期 13%低氧持续 10 分钟，5 分钟正常氧间隔）对持续低氧暴露（11.8%氧气浓度 6 小时）引起的急性低氧损伤的影响。
共招募 100 名健康志愿者，随机分为 IH 组和对照组，分别接受 IH 或假 IH 预处理 5 天，然后送入低氧舱模拟急性高原暴露（4500 米）。
急性高原病总发病率为 27%（27/100），IH 组为 14%（7/50），对照组为 40%（20/50）（p=0.003）。模拟高原暴露 6 小时后，与对照组相比，IH 组平均路易斯湖评分较低（1.30±1.27 比 2.04±1.89，p=0.024）。急性低氧暴露后平均外周血氧饱和度（SpO ）和颅内压（ICP）测量值存在显著差异，IH 组 SpO 值显著较高（85.47±5.14 比 83.10±5.15%，p=0.026），ICP 水平显著较低（115.59±32.15 比 130.36±33.83mmHg，p=0.028）。IH 预处理对血清蛋白基因产物 9.5（3.89 比 29.16pg/mL；p=0.048）和 C 反应蛋白（-0.28 比 0.41mg/L；p=0.023）也有更大的影响。
短期中度 IH 可提高对缺氧的耐受性，并对持续常压缺氧暴露引起的急性低氧损伤产生保护作用，为开发与缺氧相关疾病的治疗方法提供了一种新的方法和随机对照试验证据。
