Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Deemed to be University, Chennai, Tamil nadu, India.
Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Deemed to be University, Chennai, Tamil nadu, India.
Acta Histochem. 2022 May;124(4):151895. doi: 10.1016/j.acthis.2022.151895. Epub 2022 Apr 26.
Cancer is a disease characterised by abnormal cell growth that can invade or spread to other regions of the body. Organoids are three-dimensional ex vivo tissue cultures made from embryonic stem cells, induced pluripotent stem cells, progenitor cells or tissue that serve as a physiological model for cancer research. These are designed to recapitulate the in vivo properties of tumours. Importantly, effective recapitulation of the structure of tissues and function is believed to predict patient response, allowing for the creation of personalised therapy in a timely manner that may be used in the clinic. This Review discusses the pre-clinical model and different types of human organoids as models for the development of high throughput drug screening and also aims to highlight how organoids are shaping the future of cancer research.
癌症是一种以异常细胞生长为特征的疾病，可能会侵入或扩散到身体的其他区域。类器官是从胚胎干细胞、诱导多能干细胞、祖细胞或组织中制成的三维体外组织培养物，可用作癌症研究的生理模型。这些模型旨在重现肿瘤的体内特性。重要的是，人们认为有效重现组织的结构和功能可以预测患者的反应，从而及时创建个性化的治疗方法，这种方法可能会在临床上使用。本综述讨论了临床前模型和不同类型的人类类器官作为高通量药物筛选模型，并旨在强调类器官如何塑造癌症研究的未来。
