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预测 2016 年至 2043 年日本衰弱和痴呆症的患病率及护理经济成本:一项微观模拟模型研究。

Projecting prevalence of frailty and dementia and the economic cost of care in Japan from 2016 to 2043: a microsimulation modelling study.

机构信息

School of Public Health, University of Tokyo, Tokyo, Japan.

Walter H Shorenstein Asia-Pacific Research Center, Freeman Spogli Institute for International Studies, Stanford University, CA, USA.

出版信息

Lancet Public Health. 2022 May;7(5):e458-e468. doi: 10.1016/S2468-2667(22)00044-5.

Abstract

BACKGROUND

Dementia and frailty often accompany one another in older age, requiring complex care and resources. Available projections provide little information on their joint impact on future health-care need from different segments of society and the associated costs. Using a newly developed microsimulation model, we forecast this situation in Japan as its population ages and decreases in size.

METHODS

In this microsimulation modelling study, we built a model that simulates an individual's status transition across 11 chronic diseases (including diabetes, coronary heart disease, and stroke) as well as depression, functional status, and self-reported health, by age, sex, and educational strata (less than high school, high school, and college and higher), on the basis of nationally representative health surveys and existing cohort studies. Using the simulation results, we projected the prevalence of dementia and frailty, life expectancy with these conditions, and the economic cost for formal and informal care over the period 2016-43 in the population of Japan aged 60 years and older.

FINDINGS

Between 2016 and 2043, life expectancy at age 65 years will increase from 23·7 years to 24·9 years in women and from 18·7 years to 19·9 years in men. Years spent with dementia will decrease from 4·7 to 3·9 years in women and 2·2 to 1·4 years in men. By contrast, years spent with frailty will increase from 3·7 to 4·0 years for women and 1·9 to 2·1 for men, and across all educational groups. By 2043, approximately 29% of women aged 75 years and older with a less than high school education are estimated to have both dementia and frailty, and so will require complex care. The expected need for health care and formal long-term care is anticipated to reach costs of US$125 billion for dementia and $97 billion for frailty per annum in 2043 for the country.

INTERPRETATION

Japan's Government and policy makers should consider the potential social challenges in caring for a sizable population of older people with frailty and dementia, and a widening disparity in the burden of those conditions by sex and by educational status. The future burden of dementia and frailty should be countered not only by curative and preventive technology innovation, but also by social policies to mitigate the health gap.

FUNDING

Japan Society for the Promotion of Science, Hitachi - the University of Tokyo Laboratory for a sustainable society, and the National Institute of Ageing.

摘要

背景

痴呆症和虚弱症在老年人中常常相伴出现,需要复杂的护理和资源。现有的预测模型很少提供关于这两种疾病对来自不同社会群体的未来医疗保健需求及其相关成本的联合影响的信息。本研究使用新开发的微观模拟模型,预测日本人口老龄化和人口减少情况下这两种情况的未来趋势。

方法

在这项微观模拟模型研究中,我们根据全国代表性健康调查和现有队列研究,建立了一个模型,通过年龄、性别和教育程度(低于高中、高中和大学及以上)模拟 11 种慢性疾病(包括糖尿病、冠心病和中风)以及抑郁、功能状态和自我报告的健康状况的个体状态转换。利用模拟结果,我们预测了 2016 年至 2043 年期间日本 60 岁及以上人群中痴呆症和虚弱症的患病率、有这些疾病情况下的预期寿命以及正规和非正规护理的经济成本。

结果

在女性中,65 岁时的预期寿命将从 23.7 年增加到 24.9 年,在男性中,从 18.7 年增加到 19.9 年。女性的痴呆症发病年限将从 4.7 年降至 3.9 年,男性从 2.2 年降至 1.4 年。相比之下,女性的虚弱发病年限将从 3.7 年增加到 4.0 年,男性从 1.9 年增加到 2.1 年,所有教育组均呈此趋势。到 2043 年,预计约 29%的受教育程度低于高中的 75 岁以上女性将同时患有痴呆症和虚弱症,因此需要进行复杂的护理。预计该国 2043 年痴呆症的医疗保健和正规长期护理需求将达到每年 1250 亿美元,而虚弱症的需求将达到每年 970 亿美元。

解释

日本政府和政策制定者应考虑到照顾大量患有痴呆症和虚弱症的老年人所带来的潜在社会挑战,以及性别和受教育程度方面这些疾病负担的差距不断扩大。未来的痴呆症和虚弱症负担不仅要通过治疗和预防技术创新来应对,还要通过减轻健康差距的社会政策来应对。

资金

本研究由日本学术振兴会、日立-东京大学可持续社会实验室和日本老年医学研究所共同资助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcb9/9094718/ccc9041ff4a0/nihms-1801900-f0001.jpg

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