Brown B R, Gandolfi A J
Br J Anaesth. 1987 Jan;59(1):14-23. doi: 10.1093/bja/59.1.14.
The volatile inhalation anaesthetics have been implicated in a variety of adverse viscerotoxic reactions. In general, they have been proven to produce very few non-predicted toxicities. Hepatitis caused by halothane now seems to be the only major problem in this regard with these drugs in current practice. The evidence is convincing that this reaction is based initially on biotransformation. Thus decreases in the amount of biotransformation and lessened production of reactive metabolic products would theoretically produce a safer anaesthetic. While not perfect in all circumstances, enflurane and isoflurane come close to achieving the goal of decreased adverse viscerotoxic events.
挥发性吸入麻醉剂与多种不良内脏毒性反应有关。一般来说，已证实它们产生的非预期毒性很少。在目前的实践中，氟烷引起的肝炎似乎是这些药物在这方面唯一的主要问题。有令人信服的证据表明，这种反应最初基于生物转化。因此，理论上生物转化量的减少和活性代谢产物生成的减少会产生更安全的麻醉剂。虽然在所有情况下并不完美，但恩氟烷和异氟烷接近实现减少不良内脏毒性事件的目标。
