Harvard Medical School, Boston, MA, USA; Brigham & Women's Hospital, Boston, MA, USA.
Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Sleep Med. 2022 Jun;94:38-53. doi: 10.1016/j.sleep.2022.03.020. Epub 2022 Mar 31.
OBJECTIVE/BACKGROUND: To examine the impact of prostate cancer (PCa) on sleep health for patients and caregivers. We hypothesized that sleep disturbances and poor sleep quality would be prevalent among patients with PCa and their caregivers.
PATIENTS/METHODS: A systematic literature search was conducted according to the Preferred Reporting Items for a Systematic Review and Meta-analysis guidelines. To be eligible for this systematic review, studies had to include: (1) patients diagnosed with PCa and/or their caregivers; and (2) objective or subjective data on sleep. 2431 articles were identified from the search. After duplicates were removed, 1577 abstracts were screened for eligibility, and 315 underwent full-text review.
Overall, 83 articles met inclusion criteria and were included in the qualitative synthesis. The majority of papers included patients with PCa (98%), who varied widely in their treatment stage. Only 3 studies reported on sleep among caregivers of patients with PCa. Most studies were designed to address a different issue and examined sleep as a secondary endpoint. Commonly used instruments included the Insomnia Severity Index and European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaires (EORTC-QLQ). Overall, patients with PCa reported a variety of sleep issues, including insomnia and general sleep difficulties. Both physical and psychological barriers to sleep are reported in this population. There was common use of hypnotic medications, yet few studies of behavioral interventions to improve sleep for patients with PCa or their caregivers. Many different sleep issues are reported by patients with PCa and caregivers with diverse sleep measurement methods and surveys. Future research may develop consensus on validated sleep assessment tools for use in PCa clinical care and research to promote facilitate comparison of sleep across PCa treatment stages. Also, future research is needed on behavioral interventions to improve sleep among this population.
目的/背景：研究前列腺癌 (PCa) 对患者及其照护者睡眠健康的影响。我们假设 PCa 患者及其照护者中普遍存在睡眠障碍和睡眠质量差的情况。
患者/方法：根据系统评价和荟萃分析的首选报告项目进行了系统文献检索。为符合本系统评价的纳入标准，研究必须包括：(1) 诊断为 PCa 的患者及其照护者；以及 (2) 关于睡眠的客观或主观数据。从搜索中确定了 2431 篇文章。删除重复项后，筛选了 1577 篇摘要以确定其是否符合入选标准，然后对 315 篇进行了全文审查。
总体而言，有 83 篇文章符合纳入标准，并纳入定性综合分析。大多数论文纳入了患有 PCa 的患者（98%），他们的治疗阶段差异很大。只有 3 项研究报告了 PCa 患者照护者的睡眠情况。大多数研究旨在解决其他问题，并将睡眠作为次要终点进行检查。常用的仪器包括失眠严重程度指数和欧洲癌症研究与治疗组织核心生活质量问卷 (EORTC-QLQ)。总体而言，PCa 患者报告了多种睡眠问题，包括失眠和一般睡眠困难。该人群报告了睡眠的身体和心理障碍。该人群普遍使用催眠药物，但很少有研究采用行为干预措施来改善 PCa 患者或其照护者的睡眠。许多不同的睡眠问题是由患有 PCa 的患者和具有不同睡眠测量方法和调查的照护者报告的。未来的研究可能会就用于 PCa 临床护理和研究的经过验证的睡眠评估工具达成共识，以促进 PCa 治疗阶段之间的睡眠比较。此外，还需要对改善该人群睡眠的行为干预措施进行研究。
