Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Department of Physics and Engineering, Frostburg State University, Frostburg, MD 21532, USA.
Adv Colloid Interface Sci. 2022 Jun;304:102682. doi: 10.1016/j.cis.2022.102682. Epub 2022 Apr 22.
The rise in the use of biomaterials in bone regeneration in the last decade has exponentially multiplied the number of publications, methods, and approaches to improve and optimize their functionalities and applications. In particular, biomimetic strategies based on the self-assembly of molecules to design, create and characterize nanostructured materials have played a very relevant role. We address this idea on four different but related points: self-setting bone cements based on calcium phosphate, as stable tissue support and regeneration induction; metallic prosthesis coatings for cell adhesion optimization and prevention of inflammatory response exacerbation; bio-adhesive hybrid materials as multiple drug delivery localized platforms and finally bio-inks. The effect of the physical, chemical, and biological properties of the newest biomedical devices on their bone tissue regenerative capacity are summarized, described, and analyzed in detail. The roles of experimental conditions, characterization methods and synthesis routes are emphasized. Finally, the future opportunities and challenges of nanostructured biomaterials with their advantages and shortcomings are proposed in order to forecast the future directions of this field of research.
在过去十年中，生物材料在骨再生中的应用不断增加，与之相关的出版物、方法和技术也在不断增加，这些方法和技术旨在改善和优化生物材料的功能和应用。特别是，基于分子自组装来设计、构建和表征纳米结构材料的仿生策略发挥了非常重要的作用。我们从四个不同但相关的方面来探讨这个想法：基于磷酸钙的自固化骨水泥，作为稳定的组织支撑和再生诱导剂；优化细胞黏附并防止炎症反应恶化的金属假体涂层；作为多药物控释局部平台的生物黏附混合材料；最后是生物墨水。总结、描述和详细分析了最新生物医学设备的物理、化学和生物学特性对其骨组织再生能力的影响。强调了实验条件、表征方法和合成途径的作用。最后，提出了具有优势和缺点的纳米结构生物材料的未来机遇和挑战，以预测该研究领域的未来方向。
