Infectious Disease Epidemiology and Analytics G5 Unit, Department of Global Health, Institut Pasteur, Université de Paris, Paris, France.
Malaria Parasite Biology and Vaccines Unit, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris, Paris, France.
Parasitol Int. 2022 Oct;90:102592. doi: 10.1016/j.parint.2022.102592. Epub 2022 Apr 28.
The unique biology of Plasmodium vivax, with its ability to form latent hypnozoites in the liver stage and the early appearance of gametocytes during blood stage infection, makes it difficult to target for elimination with standard malaria control tools. Here, we use modelling studies to demonstrate that vaccines that target different stages of P. vivax could greatly assist efforts to eliminate P. vivax. Combination of vaccines that target different P. vivax life cycle stages may be required to achieve high efficacy. Our simulations demonstrate that repeated rounds of mass vaccination with multi-stage vaccines can help achieve pre-elimination levels of P. vivax in both low and high transmission settings. We review the status of global efforts to develop vaccines for P. vivax malaria. We describe the status of the leading P. vivax vaccine candidates and share some thoughts on the prospects for availability of an effective vaccine for P. vivax malaria.
间日疟原虫独特的生物学特性，包括其在肝脏阶段形成潜伏的休眠子以及在血液阶段感染早期出现配子体的能力，使得使用标准的疟疾控制工具难以将其消灭。在这里，我们使用建模研究表明，针对不同阶段的间日疟原虫的疫苗可以极大地帮助消除间日疟原虫。针对间日疟原虫不同生命周期阶段的疫苗组合可能是实现高效的必要条件。我们的模拟表明，重复进行多阶段疫苗的大规模接种可以帮助在低和高传播环境中达到消除间日疟原虫的前期水平。我们回顾了全球开发间日疟原虫疟疾疫苗的努力情况。我们描述了领先的间日疟原虫疫苗候选者的现状，并就间日疟原虫疟疾有效疫苗的供应前景分享了一些看法。
