Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Anticancer Res. 2022 May;42(5):2797-2801. doi: 10.21873/anticanres.15760.
BACKGROUND/AIM: Little is known regarding the impact of lymph node dissection on survival benefit after curative resection for pancreatic neuroendocrine tumor (PNET). This study aimed to evaluate the efficacy of lymph node dissection based on tumor location of PNET.
A retrospective study, including 50 patients with surgical resection for PNET between 2004 and 2020, was performed. The efficacy index (EI) was calculated by multiplication of the incidence of lymph node metastasis (LNM) at the station and the 5-year survival rate of patients with LNM at the station.
In the pancreatic head tumors, the peri-pancreatic head and superior mesenteric artery lymph node stations had high EI of 13.3 and 25, respectively. In contrast, other stations, including stations 8 and 12, had zero EI. In the pancreatic body and tail tumors, only the splenic artery lymph node station had a survival benefit from lymph node dissection with an EI of 6.7.
The extent of lymph node dissection for PNET should be decided based on the efficacy of lymph node dissection in accordance with tumor location. Our findings may be helpful in determining the extent of lymph node dissection required.
背景/目的：对于胰腺神经内分泌肿瘤（PNET）根治性切除术后淋巴结清扫对生存获益的影响，目前知之甚少。本研究旨在根据 PNET 的肿瘤位置评估淋巴结清扫的疗效。
对 2004 年至 2020 年间接受手术切除治疗的 50 例 PNET 患者进行了回顾性研究。通过将站别淋巴结转移（LNM）的发生率与站别 LNM 患者的 5 年生存率相乘，计算出疗效指数（EI）。
在胰头部肿瘤中，胰头周围和肠系膜上动脉淋巴结站的 EI 分别高达 13.3 和 25。相比之下，其他站别，包括站别 8 和 12，EI 为零。在胰体尾肿瘤中，只有脾动脉淋巴结站的淋巴结清扫具有生存获益，EI 为 6.7。
应根据肿瘤位置，按照淋巴结清扫的疗效来决定 PNET 的淋巴结清扫范围。我们的研究结果可能有助于确定所需的淋巴结清扫范围。
