Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong, China.
J Expo Sci Environ Epidemiol. 2023 Nov;33(6):895-902. doi: 10.1038/s41370-022-00443-8. Epub 2022 Apr 30.
There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth.
We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs.
Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored.
Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC.
We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth.
We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
目前已有研究探讨了孕期多种重金属暴露对婴幼儿早期生长发育的影响，但结果不一。
我们评估了 358 对母婴对子代在妊娠前、中、晚期尿液中 15 种重金属浓度与出生时及 1、3、6 月龄体重、身长和头围的相关性。
采用性别分层线性模型分析妊娠前、中、晚期尿液重金属浓度与婴幼儿早期生长发育的相关性，同时探索金属间的相互作用。
妊娠早期 Hg 和 V 浓度升高与男性头围、女性体重降低相关；妊娠晚期 Cs、Rb 和 Tl 浓度升高与男性体重、头围增加相关；妊娠晚期 Se 浓度升高与女性头围增加相关。另外，我们还观察到 Cs、Rb 和 Tl 与体重和头围的关联存在混杂因素。
本研究观察到孕期多种重金属暴露与婴幼儿出生后生长发育的多个潜在生物学关联。
本研究采用了全面和新颖的方法来评估孕期重金属暴露对婴幼儿早期生长发育的影响。我们的详细分析考虑了妊娠前、中、晚期 15 种不同重金属的暴露情况，以及出生时及 1、3、6 月龄体重、身长和头围等多个生长指标。
